Acetylcholinesterase activity, calcium, magnesium, and total antioxidant in uncontrolled diabetic type 2 patients treated with daonil and glucophage

الملخص EN

In this study 298 patients suffering from diabetes mellitus type 2 (150 male, and 148 female) aged between 35 to 67 years with a mean age of (45.11 ± 12.03) were included.

The study was carried out from first of November 2009 to the day 31 of May 2010.The samples were obtained from Al-Kassim hospital and Merjan Teaching Hospital in Hilla city.

The study included three groups : Firstly : 149 patients with type 2 diabetes mellitus treatment with Daonil .

Secondly: 149 patients with type 2 diabetes mellitus treatment with Glucophage .Thirdly: 83 apparently healthy subjects were chosen as healthy people.

The results show a significant increase p<0.05 in Acetyl cholinesterase AChE activity of patients treated with daonil and glocophage ≤ 5 years when compared with control group , while AChE activity found to be highly significant increase p < 0.001 in patients treated more than five years when compared with ≤ 5 years and control groups.

No differences were found in blood AChE activities between subgroups of each sample used in this study.

Corrected total calcium and ionized concentrations in DM type 2 treated with daonil and glucophage groups ≤5 and more than five years found to were highly significantly increased p < 0.001, when compared with that of the control, while there was a non-significant difference p>0.05 between the males and females when compared in the same group (control, daonil and glucophage) in all duration.

A significantly increased p < 0.001 in the corrected total calcium concentration of DM patients treatment with daonil (more than five years) when compared with that of the patients treatment with glucophage.

A significant increase p < 0.05 in magnesium concentrations in diabetes mellitus patients (daonil, and glucophage) ≤ 5 years when compared to control group.

On the other hand a highly significant increase p < 0.001 of magnesium concentrations were found in sera of DM patients more than five years when compared to DM patients ≤ 5 years and control group .No significant difference were found between males and females in control group and patients groups.

A significant decreased p < 0.05 in total antioxidant(TAC) concentration in DM patients treatment ≤5 years with daonil and glucophage was found when compared with control groups .A highly significant increase of total antioxidant p < 0.001 in sera of TCA of DM type 2 patients treated (6-15y) when compared with that of healthy control group and ≤ 5 years.

No significant difference was found in the males and females of DM type 2 patients treated with daonil and glucophage (≤ 5y or 6-15 y) when compared with control group P > 0.05.