Acute promyelocytic leukemia, study of predictive factors for differentiation syndrome, single center experience
المؤلفون المشاركون
al-Imam, Umaymah
Abd al-Muti, Dua
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 25، العدد 1 (31 مارس/آذار 2013)، ص ص. 13-19، 7ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2013-03-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Reports about patients with acute promyelocytic leukemia from the Middle East are few ; in this study we are reporting our single center experience of treating 29 patients over 6 years.
Acute promyelocytic leukemia treatment response is markedly improved after the introduction of ATRA.
Treatment related complication is still an important issue particularly Differentiation Syndrome.
Prediction to its occurrence has been tried by other groups.
We aimed to study all the possible predictive factors of acute promyelocytic leukemia.
Our chemotherapy induction protocol is AIDA protocol which includes ATRA 45 mg / m2 / d in divided doses every12 h, and Idarubicin 12 mg / m2 /d IV on days 3, 5, 7, and 9.
Differentiation Syndrome occurred in 48.3 % of patients and was mainly presented by pulmonary symptoms in 55.2 %, 6 cases died during induction.
None of the predictive factors studied showed a statistically significant difference between patients who developed Differentiation Syndrome and those who did not.
Differentiation Syndrome did not affect overall survival.
Cox regression showed an inverse yet a non significant association between PETHEMA and overall survival probability (P = 0.168).
In conclusion, Differentiation Syndrome has no clear predictive factor to date.
The best approach is to hold ATRA and give dexamethasone which is quite effective as reported in the literature.
PETHEMA risk model has a moderately significant prognostic value.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Imam, Umaymah& Abd al-Muti, Dua. 2013. Acute promyelocytic leukemia, study of predictive factors for differentiation syndrome, single center experience. Journal of the Egyptian National Cancer Institute،Vol. 25, no. 1, pp.13-19.
https://search.emarefa.net/detail/BIM-319829
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Imam, Umaymah& Abd al-Muti, Dua. Acute promyelocytic leukemia, study of predictive factors for differentiation syndrome, single center experience. Journal of the Egyptian National Cancer Institute Vol. 25, no. 1 (2013), pp.13-19.
https://search.emarefa.net/detail/BIM-319829
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Imam, Umaymah& Abd al-Muti, Dua. Acute promyelocytic leukemia, study of predictive factors for differentiation syndrome, single center experience. Journal of the Egyptian National Cancer Institute. 2013. Vol. 25, no. 1, pp.13-19.
https://search.emarefa.net/detail/BIM-319829
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 18-19
رقم السجل
BIM-319829
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر