Evaluation of the gastroprotective effect of misoprostol, chitosan and their combination on indomethacin induced gastric ulcer in rats
المؤلفون المشاركون
Ahmad, Jawad H.
al-Ahmad, Jala A. Salman
al-Masudi, Iman Abbud
المصدر
The Medical Journal of Basrah University
العدد
المجلد 29، العدد 1-2 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
تاريخ النشر
2011-12-31
دولة النشر
العراق
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background : the study was designed to evaluate the anti-ulcer effect of chitosan, misoprostol, and their combination on gastric ulceration induced by indomethacin in rats.
Methods and experimental design : chitosan was prepared from shrimp shells waste products.
Thirty rats were divided into 5 groups, 6 rats each.
Rats in group 1 (control) were given solid sugar and distilled water for 3 days ; group 2 were treated by indomethacin (25mg / rat) ; group 3, 4, and 5 were treated by misoprostol, chitosan, and by the combination chitosan and misoprostol respectively before treatment with indometacin.
Blood were collected before sacrificing the animals and used for estimation of MDA, a marker of oxidative stress.
The stomachs were prepared for estimating the total gastric area, ulcerated area, tissue MDA, mucin production as well as for histopathological examination.
Results : indometacin produced gastric ulcers, and increased the total gastric area in all animals.
These effects were associated with a significant elevation of MDA levels in the blood and in stomach tissues, and a significant reduction in mucin production.
Misoprostol, chitosan and their combination protected gastric mucosa since they significantly reduced ulcer index.
Moreover, the observed anti-ulcer effect was more with the combination in comparison to monotherapy of misoprostol or chitosan.
Treatments by misoprostol, chitosan and their combination before indometacin significantly reduced blood and tissue MDA levels and increased mucin production.
Conclusion : chitosan, misoprostol and their combination have gastroprotective effects against indometacin-induced gastric ulceration in rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ahmad, Jawad H.& al-Ahmad, Jala A. Salman& al-Masudi, Iman Abbud. 2011. Evaluation of the gastroprotective effect of misoprostol, chitosan and their combination on indomethacin induced gastric ulcer in rats. The Medical Journal of Basrah University،Vol. 29, no. 1-2, pp.1-8.
https://search.emarefa.net/detail/BIM-320765
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ahmad, Jawad H.…[et al.]. Evaluation of the gastroprotective effect of misoprostol, chitosan and their combination on indomethacin induced gastric ulcer in rats. The Medical Journal of Basrah University Vol. 29, no. 1-2 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-320765
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ahmad, Jawad H.& al-Ahmad, Jala A. Salman& al-Masudi, Iman Abbud. Evaluation of the gastroprotective effect of misoprostol, chitosan and their combination on indomethacin induced gastric ulcer in rats. The Medical Journal of Basrah University. 2011. Vol. 29, no. 1-2, pp.1-8.
https://search.emarefa.net/detail/BIM-320765
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 8
رقم السجل
BIM-320765
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر