Preparation, characterization of acid hydrazide schiff base complexes of nickel (II)‎ and their biological activity

الملخص EN

The work reported in this research deals with the preparation, characterization and biological studiesofhomodinuclearNi (II) complexeswith three Schiff base ligands.

The ligands are : dibenzoinlidenemalonoyldihydrazide (BMDH4), dibenzoinlidenesuccinyldihydrazide (BSDH4) and dibenzoinlidenephthalolyldihydrazide (BPDH4) which areobtained by the reaction ofmalonoyldihydrazide, succinyldihydrazide and phthalolyldihydrazide with benzoinin mole ratio1 : 2.

The preparation of the complexeswas carried out in both neutral and basic media and have beencharacterizedphysico -chemically and theyfound tohave the formulas [Ni2 (LH4) 2] X4 in neutral medium and [Ni2L2]in basicmediumrespectively.

Octahededralstructure has beensuggestedfo rall thehexacoordinatedcomplexes.Furthermore the complexeshave been foundto be biologically active as demonstrated by antibacterial screening against four human pathogenic bacterial stains.

It has been found that thecomplexes were more effective agent than the ligands (where X = Cl, NO3-).