Hepato-protactive activity of uritica pilulifera L leaves extract on liver functions and enzymes in diabetic rats
مقدم أطروحة جامعية
مشرف أطروحة جامعية
Abu Rajai, Talal
Mansi, Kamal M.
أعضاء اللجنة
Khalaf, Maruf A.
Mahasinah, Ihsan
Shutar, Ali
الجامعة
جامعة آل البيت
الكلية
كلية العلوم
القسم الأكاديمي
قسم العلوم الحياتية
دولة الجامعة
الأردن
الدرجة العلمية
ماجستير
تاريخ الدرجة العلمية
2009
الملخص الإنجليزي
Urtica plubifilera is utilized in folk medicine to treat severa) diseases among which is diabetes.
As the case for other plants used in folk medicine, the toxicity risks associated with use of such plants he.؛ to be evaluate To evaluate in vivo the hepatic-portal-activity and hypoglycemic potentials of the methanol extracts of Uriiica pilulifera, By enzyme assay ( AT.T; AST, ALP ) for the liver functions, protein determination ( albumin ), to determining the LD50 of u.pilulifera metabolic leaves extract, to study changes in some organs and body weight during each experiment, to estimation of some biochemical parameters for Kidney functions (urea, uric acid and keratinize concentration), and to study liver histology by sections to detect the cellular changes.
Three groups of rats were involved in this study.
The first group was exposed to ethanol treatment (lml, 15 % ethanol were administered orally every other day).
The second group was exposed to alloxan (150 ml / kg) subcutaneously.
The third group was administered by normal saline orally (control group).
The first and second groups were divided to other Sub-group which treated respectively by two doses of u.pilulifera (1.25 g / kg and 1.88g / Kg).
In ethologic groups, for the most biochemical parameters, ethanol induced significant changes in liver, kidney, and body weight.
Liver enzymes were elevated significantly compared with control group.
Kidney function tests (keratinize, urea and uric acid) were elevated significantly compared with control group.
After treatment by two different doses of u.pilulifera (1.25 g / kg.
1.88 g / kg), all previous parameters were restored significantly compared with control.
Diabetes was induced by alloxan after treatment with u.
pilufera both of liver function test, and kidney test were restored significantly compared with diabetic group.
Immunohistological studies showed increased expression level ofHSP70 and INOS in liver and kidney due to diabetes and ethanol treatment.
even u.
pilulifera treatment induced significant changes on liver and kidney function tests, but its effects on expression of both ofHSP70 and INOS was not statistically significant.
The use of u.
pilulifera was proved to have significant effects in reducing the adverse effects of ethanol toxicity and diabetes.
From molecular point of view, the use of u.
pilulifera needs to be more validated since adverse effects in terms of expression of INOS are still forming risk factors.
التخصصات الرئيسية
الموضوعات
عدد الصفحات
97
قائمة المحتويات
Table of contents.
Abstract.
Chapter One : introduction.
Chapter Two : literature review.
Chapter Three : materials and methods.
Chapter Four : results.
Chapter Five : discussion.
References.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Ayish, Fatimah. (2009). Hepato-protactive activity of uritica pilulifera L leaves extract on liver functions and enzymes in diabetic rats. (Master's theses Theses and Dissertations Master). Al albayt University, Jordan
https://search.emarefa.net/detail/BIM-321504
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Ayish, Fatimah. Hepato-protactive activity of uritica pilulifera L leaves extract on liver functions and enzymes in diabetic rats. (Master's theses Theses and Dissertations Master). Al albayt University. (2009).
https://search.emarefa.net/detail/BIM-321504
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Ayish, Fatimah. (2009). Hepato-protactive activity of uritica pilulifera L leaves extract on liver functions and enzymes in diabetic rats. (Master's theses Theses and Dissertations Master). Al albayt University, Jordan
https://search.emarefa.net/detail/BIM-321504
لغة النص
الإنجليزية
نوع البيانات
رسائل جامعية
رقم السجل
BIM-321504
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر