Synthesis of some pyrimidine-2-one and pyrimidine-2-thione compounds

الملخص EN

An efficient synthesis of chalcones (1-7) was achived by condensation of substituted benzaldehyde with substituted acetophenone in ethanolic sodium hydroxide (50 %).

The chalcones were reacted with urea and thiourea to give the pyrimidinones (8-14) and pyrimidinethiones (15-21) respectively.

All the prepared compounds were confirmed by the available physical and spectral methods.