The use of oxidation reaction for the spectrophotometric determination of ganciclovir in pharmaceutical formulations

الملخص EN

A simple and sensitive spectrophotometric method was developed for the determination of ganciclovir (GCV) in a bulk drug and in its pharmaceutical formulations.

The method was based on the reduction of potassium permanganate by ganciclovir in alkaline medium to form a green colour product showing maximum absorbance at 610 nm.

Beer's law is obeyed in the concentration range 2-100 μg.ml-1 with average recovery (accuracy) 100.24 % and precision (RSD) is less than 1.0 %.

The molar absorptivity is 4.59 x 103 l.mol-1.cm-1 with LOD 0.21 μg.ml-1 and LOQ 0.72 μg.ml-1.

The proposed method was further applied to the determination of the drug in pharmaceutical formulations as an injection and capsule and the results are compatib.