Alleviation of cisplatin-induced nephrotoxicity in rats by aqueous extract of salvia officinalis leaves

الملخص EN

Objectives : To evaluate the protective effects of the aqueous extract of Salvia officinalis leaves against nephrotoxicity induced by cisplatin in rats.

Methods: Albino rats were divided into three groups, each group consist of six rats.

Group I treated with vehicle (distilled water) was kept as a control.

Group II injected with a single dose of cisplatin (12 mg / kg body weight; i.p.).

Rats in Groups III were received a single daily dose of aqueous extract of S.

officinalis 100 mg / kg (P.O.), for 7 days.

On the seventh day, cisplatin (12 mg / kg body weight ; i.p.

was administered half an hour after the last dose of the plant extract.

The rats in all groups were sacrificed 72 h after treatment.

Renal injury was assessed using serum biochemical markers (creatinine and urea).

Malondialdehyde (MDA) concentration was measured as a marker of lipid peroxidation.

The renoprotecive activity of S.

officinalis was supported by histopathological studies of the kidney.

Results : Aqueous extract of S officinalis leaves significantly protected rat kidneys from cisplatin-induced histopathological changes.

This extract also normalized cispaltin induced increases in serum creatinine and blood urea.

In vitro studies revealed that the S officinalis leaf extract possessed significant oxidative radical scavenging activities.

Conclusion : Both biochemical findings and histopathological evidence showed the renoprotective potential of aqueous extract of S.

officinalis leaves against cisplatininduced oxidative stress and renal dysfunction in rats.