Biochemical and demographical study of lipid profile in sera of patients with gallstone

الملخص EN

Thirty patients with gallstone [aged 25-55 years] and thirty age-and sex-matched healthy subjects as control group were involved.

Those patients were intended to undergo surgical removal of gallbladder in the surgical ward- Al Sadder Teaching Hospital and AL-Hakeem Hospital in Najaf city during the period from July / 2009 to December / 2009.

The proportion of female was [86 %] compared to the male t [14 %].

The ratio of female: male was 5 : 1.

Blood samples were obtained from all patients prior to surgery.

Serum was obtained by usual methods and analyzed for lipid profile test [total cholesterol [TC], triglyceride [TG], high density lipoprotein-cholesterol [HDL-C], low density lipoprotein cholesterol [LDL-C] and very low density lipoprotein cholesterol [VLDL-C]}.

The results showed that there were no significant differences between gallstone patients and control regarding HDL-C [p > 0.05] but there was highly significant [p > 0.05] difference in the concentrations of total cholesterol [TC], triglyceride [TG] and VLDL-C comparing with the control group.

The study also showed that the sex has a significant effect [p>0.05] on the levels of TC, LDL-C, and VLDL-C in sera of patients with gallstone whereas, non-significant sex variation had found with respect to HDL-C level.

On the other hand, it was also found that there was a significant p>0.05 ] age variations with respect to serum levels of TC, TG and VLDL-C with effect with respect to both HDL-C and LDL-C levels in sera of patient with gallstone.

Additionally, all items of lipid panel found to be significantly [p > 0.05] varied with respect to the BMI.

Similarly, smoking was found to be important cause and revealed a significant [p > 0.05] difference regarding all parameters- but not LDL-C of lipid components.

The objective of this study was to estimate the serum lipid profile, in sera of patients with gallstone and investigate their relationship with demographic factors.