Multidisciplinary treatment in children with non-metastatic hepatoblastoma : treatment results at the national cancer institute, Cairo university

المؤلفون المشاركون

Zamzam, Manal A.
al-Malt, Usama
Abu al-Qasim, Hatim
al-Basmy, Ayman
Nuh, Akram

المصدر

Journal of the Egyptian National Cancer Institute

العدد

المجلد 16، العدد 2 (30 يونيو/حزيران 2004)، ص ص. 92-98، 7ص.

الناشر

جامعة القاهرة المعهد القومي للأورام

تاريخ النشر

2004-06-30

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الطب البشري

الموضوعات

الملخص EN

Purpose : The aim of this study is to evaluate our experience at the NCI, Cairo University in the management of non- metastetic hepatoblastoma (HB).

Also to improve survival of children with HB and reduce the operative morbidity and mortality by using preoperative chemotherapy.

Patients and Methods : After biopsy and assessment of the extent of disease, all patients were treated with a 6-hour continuous intravenous infusion of cisplatin (PLA) 90mg/m2 on day one followed by doxorubicin (DO) 20mg/m2 per day administered as 1- hour infusion on days 2,3 and 4.

After four courses of preoperative chemotherapy, patients were reassessed.

Whenever possible, the primary tumor was resected and the treatment was completed with two more courses of chemotherapy.

Results: Twenty children with HB were registered between January 1999 and December 2000, the median age at diagnosis was 12 months (range, 40 days to 11 years).

All the 20 patients had received preoperative chemotherapy (PLADO).

Fifteen patients (75%) showed partial response with tumor shrinkage and serial decrease of serum alpha-fetoprotein levels.

Sixteen patients underwent surgery, fourteen of them had complete resection of the primary tumor (87.5%).

The median duration of followup was 26 months (range 1-55 months).

The three year disease-free survival was 68.4% and event-free survival was 65%.

Conclusion : We can advocate the use of PLADO chemotherapy and delayed surgery to be the standard treatment for children with HB.

Other treatment programs should be measured against this standard.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zamzam, Manal A.& al-Malt, Usama& Abu al-Qasim, Hatim& Nuh, Akram& al-Basmy, Ayman. 2004. Multidisciplinary treatment in children with non-metastatic hepatoblastoma : treatment results at the national cancer institute, Cairo university. Journal of the Egyptian National Cancer Institute،Vol. 16, no. 2, pp.92-98.
https://search.emarefa.net/detail/BIM-32373

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Abu al-Qasim, Hatim…[et al.]. Multidisciplinary treatment in children with non-metastatic hepatoblastoma : treatment results at the national cancer institute, Cairo university. Journal of the Egyptian National Cancer Institute Vol. 16, no. 2 (Jun. 2004), pp.92-98.
https://search.emarefa.net/detail/BIM-32373

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zamzam, Manal A.& al-Malt, Usama& Abu al-Qasim, Hatim& Nuh, Akram& al-Basmy, Ayman. Multidisciplinary treatment in children with non-metastatic hepatoblastoma : treatment results at the national cancer institute, Cairo university. Journal of the Egyptian National Cancer Institute. 2004. Vol. 16, no. 2, pp.92-98.
https://search.emarefa.net/detail/BIM-32373

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references : p. 98

رقم السجل

BIM-32373