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Hypofractionation versus conventional fractionation radiotherapy after conservative treatment of breast cancer : early skin reactions and cosmetic results
المؤلفون المشاركون
Tahir, Azzah N.
al-Baradii, Manal M.
Isa, Hibah
Zaki, Umar
al-Zayyat, Sumayyah
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 16، العدد 3 (30 سبتمبر/أيلول 2004)، ص ص. 178-187، 10ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2004-09-30
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الموضوعات
الملخص EN
Purpose : To compare in a prospective trial the acute skin reaction and late cosmetic effects of normal fractionation versus hypofractionation radiotherapy after breast conserving surgery.
Patients and Methods: Thirty patients with T1-2N0M0 breast cancer who underwent breast conserving surgery (BCS) were included in the study.
Half of the patients received whole breast irradiation, consisting of 50 Gy/25f/5w+boost 10Gy/5f/1w to tumor bed (group A).
The other half received 42.5Gy/16f/22 days (group B).
The two groups were comparable otherwise.
Early skin reaction and late cosmetic results were graded according to RTOG guidelines.
Results : The study showed no statistical significant difference between the two treatment groups as regards acute skin reactions and cosmetic appearance.
However, the maximum skin reaction occurred 2 weeks earlier for patients within group B (3rd week) compared to group A (5th week).
Apart from breast volume, there was no significant correlation between any of the patients or tumor factors and the incidence of acute skin reactions in either group of patients.
Patients with large breast volume >1100cc had a higher rate and a longer duration of maximum skin reaction in group A (4 weeks versus 2 weeks in patients with small breast volume ?1100cc), while in group B, all patients had a maximum duration of 4.5 weeks.
This difference was not statistically significant.
After median follow-up of 22 months, again there was no difference between the two groups as regard the cosmetic outcome.
Lumpectomy volume and lumpectomy / breast volume ratio (regardless of the tumor volume) were the only factors that significantly affected the cosmetic appearance.
Conclusions : Preliminary results support the use of a shorter fractionation schedule of 42.5Gy / 16f / 22 days in patients with breast conserving surgery.
The study is still going on to study the late effects on a larger number of patients for final evaluation of this regimen.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tahir, Azzah N.& al-Baradii, Manal M.& Isa, Hibah& Zaki, Umar& al-Zayyat, Sumayyah. 2004. Hypofractionation versus conventional fractionation radiotherapy after conservative treatment of breast cancer : early skin reactions and cosmetic results. Journal of the Egyptian National Cancer Institute،Vol. 16, no. 3, pp.178-187.
https://search.emarefa.net/detail/BIM-32416
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tahir, Azzah N.…[et al.]. Hypofractionation versus conventional fractionation radiotherapy after conservative treatment of breast cancer : early skin reactions and cosmetic results. Journal of the Egyptian National Cancer Institute Vol. 16, no. 3 (Jun. 2004), pp.178-187.
https://search.emarefa.net/detail/BIM-32416
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tahir, Azzah N.& al-Baradii, Manal M.& Isa, Hibah& Zaki, Umar& al-Zayyat, Sumayyah. Hypofractionation versus conventional fractionation radiotherapy after conservative treatment of breast cancer : early skin reactions and cosmetic results. Journal of the Egyptian National Cancer Institute. 2004. Vol. 16, no. 3, pp.178-187.
https://search.emarefa.net/detail/BIM-32416
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 186-187
رقم السجل
BIM-32416
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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