Salivary and seral sex steroid hormones variation among group of peoples with gingivitis

الملخص EN

Background : This study aimed to determine the level of sex steroid hormones (estradiol, testosterone) in the sera and saliva of the patients and controls, also to establish the type of correlation between the change in the biochemical inflammation markers (ALP, C-RP, IL-6, ALb) and levels of sex hormones (estradiol, testosterone) in gingivitis patients and control. Sample and Methods : The work included ninety samples (serum and saliva) of 45 volunteers (22males and 23females), twenty one patients with gingivitis and twenty four healthy subjects as control group. Results : the results showed a highly significant increase (p < 0.001) in IL-6 for male in serum and saliva samples while significant increase (p < 0.05) for females And a highly significant increase (p < 0.001) in ALP activity in serum and saliva while significant increase (p < 0.05) in specific activity of ALP for serum and saliva in both (male and female), and a non-significant decrease ALB Level (p > 0.05) in serum and saliva in patients with gingivitis.

The levels of serum and saliva testosterone were significantly decrease (p < 0.05) in gingivitis than healthy group.

While estradiol level was highly significant increase (p < 0.001) in saliva and serum gingivitis patients in compared to the healthy group.

The results of studying the correlation between the above parameters indicated there were a highly significant positive correlation obtained is between sera E2 with (ALP, IL-6,) and between sera testosterone with (ALP, IL-6), and between saliva testosterone with albumin .while negative correlation between sera E2 with ALB, and between saliva E2 with all three inflammation marker (i.e.

ALP, albumin and IL-6), also negative association was found between sera testosterone with ALB and between salivary testosterone with (ALP and IL-6). Conclusion : the results generated from this study could lead to improvement in gum care program for peoples and revealed an association between gingivitis progression with hormonal changes production as result to increase the inflammation marker (ie IL-6, ALP). Also saliva analysis is better for determination the free bioavailable steroid hormones than sera analysis