Clinical and histopathological investigation of ivermectin toxicity in pigeons

الملخص EN

The aim of this study was to investigate the clinical signs and histopathological changes of acute toxicity of ivermectin in the centeral and peripheral nervous system liver, kidney, pancreas and heart of pigeons after s / c injection with ivermectin .Eighteen bird were divided into three equal groups.

Group A were injected with 8mg,group B were injected with 10 mg and group C served as control group.

The results showed markedy reduced of water and food consumption ,somnolence and death of treated pigeons.

Nervous signs were restlessness, ataxia, un steady gait, tremor and recumbent.

The histopathological changes included degeneration of nerve fibers of spinal cord and sciatic nerve .Degeneration , necrosis and vacuolation were noticed in liver, kidney and heart, as wll as proliferation of bile duct was also seen in liver.