Comparative study on pesticide mixture of organophosphorus and pyrethroid in commercial formulation

الملخص EN

Mixing organophosphate and pyrethroid becomes very common in the insecticide markets in the developing countries and result in an increase in the prevalence of mixed toxicity.

The present study aimed to evaluate the toxic effects of a commercial preparation of a pesticide mixture Durasin, which contains 60 % diazinon (DA) and 0.5% deltamethrin (DM), compared to the individual commercial pesticides of 30% DA and 5% DM.

Cholinesterase (ChE), malonaldehyde (MDA), glutathione (GSH), glutathione-S-transferase (GST), superoxide dismutase (SOD), total cholesterol (TC), triglyceride (TG) and non-specific esterase's isoenzymes in blood of male albino rats were determined after 7 and 14 days of treatment.

The weekly recorded biochemical results were used as criteria for estimating the joint action of the tested pesticide mixture.

Antioxidant defense mechanism and lipid peroxidation in rat plasma displayed the same responses with different intensity depending on the different treatments.

Biochemical analysis showed that administration of DA and DM caused alterations in lipid metabolism and non-specific esterase.

The results also revealed that the mixture induced antagonistic effects toward all the tested parameters except the total reduced glutathione level, which was synergetic at the 2nd week.

The study pointed out to the importance of performing biochemical tests on the commercial mixture of insecticides.