Relationship between some immunological aspects and psoriasis among Iraqi psoriatic patients

الملخص EN

Psoriasis is a chronic inflammatory skin disorder, word wide.

The pattern of cytokine expression suggests that Th1 may mediate or maintain psoriasis disease.

IL-12 plays a major role in the development of Th1-cell mediated immune responses. Materials & Methods: Eighty cases of psoriatic patients have been studied.

Patients were grouped as mild psoriasis group ( 32) and severe psoriasis group (48) according to severity, and (30) apparently healthy individuals used as control group, sera samples of all groups were collected for estimation IL-12,immunoglobulines (IgM, IgA, IgG),and diagnosis serum positivity for streptolysin - O antibody and C-reactive protien tests. Results and Conclusions: Serum IL-12 was significantly increasing among psoriatic patients as compared to healthy controls(46.9pg / ml and 39 pg / ml) respectively.

It was concluded that (IL-12) has asignificant role during the acute phase of disease.

Significant differences between all psoriatic patients and healthy control as well as between two types of psoriatic patients could be detected in IgA , and IgG levels , while serum IgM levels were significantly increased in the both types of illness compared to healthy controls.

It was concluded that (IL-12) has asignificant role during the acute phase of disease.

Presence of A.S.O and CRP positivity in serum of some patients refer to that infection with Streptococcal bacteria could be it is the triggered to the psoriasis in those patients, and a positive correlation was founded between IL-12 and CRP.