Use of simvastation as antioxidant drug significantly decreases lipid peroxidation by utilization of malondialdehyde (mad)‎ level assay as an indicator of spermatozoal oxidative stress in male infertile patient

الملخص EN

A randomized blind controlled study is carried out on a total of 55 patient with primary male factor infertility in Maternity and Childhood Teaching Hospital in Najaf Province between April 2005-June 2006.

The distribution of patients in group I were classified into 8 subgroups according to pathological cause of infertility and group II consisted of 35 normal proven fertility volunteer men served as a control group.

All patients were given simvastation tables at dose 20 mgt twice daily for a period of 3 months.

Semen samples and spermatozoal malondialdehyde level (MDA) level were assessed in all infertile subgroup patients before administration and after termination of treatment while group II were assisted as a control group.The present results showed that there was a negative relation between malondialdehyde level (MDA) and active sperm motility % and positive relation between MDA and abnormal sperm morphology.This study suggests that simvastation might be administered as an antioxidant drug to reduce lipid peroxidation and the later as as an index of malondialdehyde (MDA) level assay in oxidatively stressed infertile patients.