Evaluation of the clinical effect of melatonin on oxidative stress markers in patients with lead poisoning
العناوين الأخرى
التقييم السريري لتأثير الميلاتونين على مؤشرات الجهاد التأكسدي لمرضى التسمم بالرصاص
المؤلفون المشاركون
Najm al-Din, Ashwaq
Muhammad, Muhammad Mahmud
al-Rikabi, Muhammad Dakhil
المصدر
العدد
المجلد 12، العدد 2 (31 ديسمبر/كانون الأول 2009)، ص ص. 177-185، 9ص.
الناشر
تاريخ النشر
2009-12-31
دولة النشر
العراق
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
Lead is a neurotoxic metallic element that can be absorbed by the body, primarily through the lungs and stomach.
Generally, lead poisoning occurs slowly, resulting from the gradual accumulation of lead in bone and tissue after repeated exposure.
Left untreated, lead poisoning can damage many internal organs, including the kidney, nervous system and brain.
Recent studies have shown that lead causes oxidative stress by inducing the generation of reactive oxygen species (ROS) and reducing the antioxidant defense system of cells.
This suggests that antioxidants may play an important role in the treatment of lead poisoning as a kind of excellent scavenger of free radicals.
Antioxidant any substance that reduces oxidative damage (damage due to oxygen) such as that caused by free radicals.
Free radicals (FRs) are highly reactive chemicals that attack molecules by capturing electrons and thus modifying chemical structures.
Melatonin (a powerful antioxidant) is a hormone produced naturally in the pineal gland at the base of the brain.
This study was designed to evaluate the clinical significance of melatonin in ameliorating the oxidative stress induced due to chronic exposure to lead.
Twenty male patients with chronic lead poisoning with their 20 aged matched controls were included in this study.
Treatment included 3 mg capsule of melatonin antioxidant at night for two months.
Heparinized venous blood samples were collected from patients before treatment and at one and two months after treatment as well as from controls to measure erythrocytes malondialdehyde (RMDA), plasma total antioxidant status (TAS), blood lead (Pb) and serum zinc (Zn)levels.
The result of the study showed a significant antioxidant activity of melatonin in eliminating the oxidative consequences of lead exposure revealed by significant reduction in oxidative stress markers ( RMDA and Pb) with a significant increase in body antioxidant defense mechanisms(TAS and Zn).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Rikabi, Muhammad Dakhil& Najm al-Din, Ashwaq& Muhammad, Muhammad Mahmud. 2009. Evaluation of the clinical effect of melatonin on oxidative stress markers in patients with lead poisoning. Kufa Medical Journal،Vol. 12, no. 2, pp.177-185.
https://search.emarefa.net/detail/BIM-327140
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Najm al-Din, Ashwaq…[et al.]. Evaluation of the clinical effect of melatonin on oxidative stress markers in patients with lead poisoning. Kufa Medical Journal Vol. 12, no. 2 (2009), pp.177-185.
https://search.emarefa.net/detail/BIM-327140
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Rikabi, Muhammad Dakhil& Najm al-Din, Ashwaq& Muhammad, Muhammad Mahmud. Evaluation of the clinical effect of melatonin on oxidative stress markers in patients with lead poisoning. Kufa Medical Journal. 2009. Vol. 12, no. 2, pp.177-185.
https://search.emarefa.net/detail/BIM-327140
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 184-185
رقم السجل
BIM-327140
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر