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Serum resistin and anthropometric parameter in lean and overweight insulin–dependent diabetic children (IDDM)
المؤلفون المشاركون
al-Yasin, Hadif Zafir
al-Ani, Manal K. Rashid
Majad, Ban A.
al-Nidawy, Mahjub
المصدر
العدد
المجلد 12، العدد 2 (31 ديسمبر/كانون الأول 2009)، ص ص. 294-305، 12ص.
الناشر
تاريخ النشر
2009-12-31
دولة النشر
العراق
عدد الصفحات
12
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : type 1 diabetes mellitus is a multifactorial syndrome due to a body's inability to synthesis insulin.
In patients with type 1 DM, the beta cells are attacked by the immune system (specifically by macrophages and T lymphocytes) and killed, so insulin can no longer be synthesised.
Resistin is a newly identified adipocyte secreted hormone belonging to a cysteine-rich protein family.
Human resistin gene is expressed in pancreatic islets, pre-adipocytes and bone marrow.
It is of relevance for inflammation processes as well as for lipid metabolism.
The body mass index BMI a measured of relative weight, adjusted for height.
Resistin serum levels were found to be related to body mass index (BMI) in human subjects.
Waist circumference is minimally related to height, so correction for height (as in waist to height ratio) dose not improve its relation with intra- abdominal fat or ill health Objective : the aim is to determin the role of Resistin in lean and overweight.
Subjects and methods : sixty diabetic children 33 males and 27 females), aged (1.3-13))years (mean ± SD) (5.6 ± 2.8) years , were enrolled in this study.
All had T1DM with no serious long-term complications and C-reactive protein for all patients was negative.
All patients used short- and intermediate-acting subcutaneous insulin injections (two daily injections) and no other medication.
Duration of disease varied from (0.13- 84) months.
A matching group of thirty healthy volunteer children with age range of (13-1.3) years, (18 females, 12 males) were included as a control without any family history of diabetes.
Serum Rresistin was measured by (enzyme linked immunosorbant assay, ELISA) .
Anthropometric determined are measured as BMI and WHR.
BMI (weight in kg divided by the square of the height in meters), Waist and hip circumferences were measured to determine waist-hip ratio (WHR) following standardized procedures.
Results : Resistin values showed no significant difference when comparing both groups (patients and controls).
A significant decrease in the level of fasting serum Resistin was found in overweight patients when compared to control, while no such significance was shown for serum Resistin in lean patients when compared to controls.
However a significant correlation was found when comparing serum Resistin and BMI in controls but the correlation was not significant in patients.
Conclusion : Resistin levels was found to be highly associated with obesity in healthy controls with a significant elevation in overweight when compared to lean sunjects.
However the opposite was found in patients under treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Ani, Manal K. Rashid& Majad, Ban A.& al-Yasin, Hadif Zafir& al-Nidawy, Mahjub. 2009. Serum resistin and anthropometric parameter in lean and overweight insulin–dependent diabetic children (IDDM). Kufa Medical Journal،Vol. 12, no. 2, pp.294-305.
https://search.emarefa.net/detail/BIM-327226
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Ani, Manal K. Rashid…[et al.]. Serum resistin and anthropometric parameter in lean and overweight insulin–dependent diabetic children (IDDM). Kufa Medical Journal Vol. 12, no. 2 (2009), pp.294-305.
https://search.emarefa.net/detail/BIM-327226
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Ani, Manal K. Rashid& Majad, Ban A.& al-Yasin, Hadif Zafir& al-Nidawy, Mahjub. Serum resistin and anthropometric parameter in lean and overweight insulin–dependent diabetic children (IDDM). Kufa Medical Journal. 2009. Vol. 12, no. 2, pp.294-305.
https://search.emarefa.net/detail/BIM-327226
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 304-305
رقم السجل
BIM-327226
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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