Effect of magnesium sulfate on inflammatory response in coronary artery bypass grafting surgery

الملخص EN

Background / Aim : On-pump coronary artery bypass graft surgery is associated with a marked systemic inflammatory response.

The aim of this study was to investigate whether magnesium which has been reported to have anti-inflammatory activity in many diseases and its deficiency leads to a state of inflammation experimentally and in vivo which can be treated by magnesium administration.

We conduct this study to examine this hypothesis that giving magnesium could reduce inflammatory response in this high-risk category of patients. Patients and Methods : In this randomized prospective double blinded study, 20 patients undergoing elective coronary artery bypass grafting surgery were divided randomly into two groups to receive either MgSO4 30 mg / kg bolus over 10 minutes then continued as infusion at a dose of 30 mg/kg/h (magnesium group) or an equal amount of isotonic sodium chloride solution (Control group).

Inflammatory markers were studied IL-6, IL-8, TNF-α and C-reactive protein (CRP).

These markers were collected preoperatively on arrival to the operating room (T0), 15 minutes after CPB (T1), at skin closure (T2) and postoperatively at 4 hours (T3) and 24 hours (T4).

The levels of pro-inflammatory markers were compared to the preoperative value in each group, and then comparison between the two groups at the different times of the study was done. Results : There were significant increases in the pro-inflammatory markers (IL-6, IL-8, TNF-α & CRP) in both groups.

The magnesium group had significant lower levels of the pro-inflammatory markers (IL-6, IL-8, TNF-α and CRP) throughout the study compared to the control group. Conclusion : Use of magnesium sulfate during coronary artery bypass Grafting surgery significantly lowers the levels of the pro-inflammatory markers (IL-6, IL-8, TNF-α and CRP).