The effect of periodontal treatment on circulating tumor necrosis factor-alpha and insulin resistance in patients with type 2 diabetes mellitus

الملخص EN

The aim of this study is to investigate the effect of periodontal treatment on the relation between inflammation and insulin resistance in patients with type 2 diabetes mellitus.

Group I included 15 type -2 diabetic patients with chronic periodontitis; Group II were systemically healthy 15 patients with chronic periodontitis and family history of Type 2 diabetes mellitus ; while Group III included 10 Type 2 diabetic patients without chronic periodontitis and was considered as a control group.

Circulating TNF-α level, glycated hemoglobin, fasting blood glucose, fasting human serum insulin concentration as well as insulin sensitivity assessed using HOMA-IR were measured before and after 3 months of periodontal treatment that were composed of conventional mechanical treatment with adjunctive systemic doxycycline therapy.

Higher levels of the assessed parameters were observed in type 2 diabetic patients with periodontitis compared to those without periodontitis.

Circulating TNF-α level significantly was reduced after periodontal treatment.

The results indicate that periodontal treatment was effective in improvement of insulin sensitivity and glycemic control in Type 2 diabetics, which could be explained by reduced serum TNF-α with its insulin resistance mediated effect.