Tumor necrosis factor-alfa and monocyte chemoattractant protein-1 gene polymorphisms in kidney transplant recipients
المؤلفون المشاركون
Mahmud, Majid S.
Nasr al-Din, Iman
Muhammad, Wafa Sayyid
al-Ghazzawi, Ibtisam M.
Said, Siham Ahmad
Ibrahim, Maha Atwa
Abd al-Latif, Hanan Harith
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 24، العدد 4 (31 ديسمبر/كانون الأول 2013)، ص ص. 688-695، 8ص.
الناشر
تاريخ النشر
2013-12-31
دولة النشر
السعودية
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
- المرضى
- الكلى
- زرع الأعضاء
- الالتهاب
- تعدد الأشكال الوراثية
- الجوانب الوراثية
- السيتوكينات
- وحيدات النوى
- عامل نخر الورم
- الخلايا البلعمية
الملخص EN
Tumor necrosis factor-alfa (TNF-α) gene polymorphism is supposed to have a significant influence on the incidence of acute rejection in renal transplantation.
The monocyte chemoattractant protein-1 (MCP-1) is another factor supposed to modulate graft rejection.
We studied TNF-α and MCP-1 gene polymorphisms in 84 kidney allograft recipients with polymerase chain reaction and restriction fragment length polymorphism and their serum levels by enzyme-linked immunosorbent assay.
The patients were classified into two groups based on their outcomes : Group I (n = 47) recipients with stable graft function as the control group and group II (n = 37) recipients who experienced acute graft rejection episodes in the first 30 days post-transplantation.
A significantly higher incidence of TNF 2 / TNF 2 genotype was observed among patients with acute graft rejection in comparison with the control group (40.5 % and 19.2 % respectively, P < 0.05), while no statistically significant differences were observed in the TNF 1 / TNF 1 genotype between the groups (59.4 % and 80.8 %, respectively, P > 0.05).
A significant elevation of serum TNF-α levels was found in group II than group I and between TNF 2 genotype compared with that of TNF1 genotype within group II recipients.
Distribution of MCP-1 genotypes in patients with and without acute rejection episodes was not significantly different (70.2 % and 76.6 % for MCP-1 A / A and 29.7 % and 23.4 % for MCP-1 G / G, respectively, P > 0.05).
The serum MCP-1 levels were not significantly different between the groups and between MCP-1 G / G genotype and MCP-1 A / A genotype in group II recipients.
In conclusion, TNF-α gene polymorphism or its serum levels may identify patients at risk of acute rejection, where patients with TNF 2 / TNF 2 genotype or high serum TNF-α levels are more likely to have acute rejection episodes, while there was no relation between MCP-1 genotype or its serum levels and acute rejection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Ghazzawi, Ibtisam M.& Nasr al-Din, Iman& Muhammad, Wafa Sayyid& Mahmud, Majid S.& Abd al-Latif, Hanan Harith& Ibrahim, Maha Atwa…[et al.]. 2013. Tumor necrosis factor-alfa and monocyte chemoattractant protein-1 gene polymorphisms in kidney transplant recipients. Saudi Journal of Kidney Diseases and Transplantation،Vol. 24, no. 4, pp.688-695.
https://search.emarefa.net/detail/BIM-328468
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ibrahim, Maha Atwa…[et al.]. Tumor necrosis factor-alfa and monocyte chemoattractant protein-1 gene polymorphisms in kidney transplant recipients. Saudi Journal of Kidney Diseases and Transplantation Vol. 24, no. 4 (2013), pp.688-695.
https://search.emarefa.net/detail/BIM-328468
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Ghazzawi, Ibtisam M.& Nasr al-Din, Iman& Muhammad, Wafa Sayyid& Mahmud, Majid S.& Abd al-Latif, Hanan Harith& Ibrahim, Maha Atwa…[et al.]. Tumor necrosis factor-alfa and monocyte chemoattractant protein-1 gene polymorphisms in kidney transplant recipients. Saudi Journal of Kidney Diseases and Transplantation. 2013. Vol. 24, no. 4, pp.688-695.
https://search.emarefa.net/detail/BIM-328468
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 694-695
رقم السجل
BIM-328468
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر