Metabolic evaluation in first-time renal stone formers in north India : a single center study
المؤلفون المشاركون
Joshi, Akhil
Gupta, Sushil Kumar
Srivastava, Aneesh
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 24، العدد 4 (31 ديسمبر/كانون الأول 2013)، ص ص. 838-843، 6ص.
الناشر
تاريخ النشر
2013-12-31
دولة النشر
السعودية
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
The risk of stone recurrence in first-time stone formers (FTSF) varies from 26 % to 53 %.
There is no consensus regarding metabolic evaluation in these individuals.
We evaluated the metabolic abnormalities in first-time renal stone forming patients in North India.
Thirty-nine patients, (29 males and 10 females with mean age 39.3 ± 12.9 years) who presented with nephrolithiasis for the first time were evaluated.
We evaluated the calcium homeostasis [serum corrected total calcium, phosphorous, creatinine, alkaline phosphatase, albumin, parathormone (iPTH), 25-hydroxy cholecalciferol (25 (OH) D 3), 1-25 di-hydroxy cholecalciferol (1, 25(OH) 2 D 3)] and performed the calcium load test also.
Two 24-h urine collections were taken for citrate, oxalate, calcium and uric acid.
Ammonium chloride loading test for diagnosis of distal renal tubular acidosis was performed in all patients.
For each of the diagnostic categories, descriptive statistics were computed for all biochemical variables.
A two-tailed P-value < 0.05 was regarded as significant.
Metabolic abnormalities were detected in 92.3 % of the patients (n = 39) studied.
Of them, almost 60 % had two or more metabolic abnormalities.
The most common metabolic abnormality was hypo-citraturia (82 %), followed by hyper-oxaluria (56 %) and hyper-calciuria (41 %).
Five percent of the patients had incomplete renal tubular acidosis, signifying the importance of the ammonium chloride loading test in patients with renal stones.
None of the study patients were detected to have primary hyperparathyroidism.
In three patients, the etiology could not be detected.
Our findings suggest that an underlying disorder is present in majority of first-time renal stone formers.
Intervention with appropriate treatment can prevent recurrences.
Hence, comprehensive metabolic evaluation is recommended in all FTSF.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Joshi, Akhil& Gupta, Sushil Kumar& Srivastava, Aneesh. 2013. Metabolic evaluation in first-time renal stone formers in north India : a single center study. Saudi Journal of Kidney Diseases and Transplantation،Vol. 24, no. 4, pp.838-843.
https://search.emarefa.net/detail/BIM-328743
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Joshi, Akhil…[et al.]. Metabolic evaluation in first-time renal stone formers in north India : a single center study. Saudi Journal of Kidney Diseases and Transplantation Vol. 24, no. 4 (2013), pp.838-843.
https://search.emarefa.net/detail/BIM-328743
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Joshi, Akhil& Gupta, Sushil Kumar& Srivastava, Aneesh. Metabolic evaluation in first-time renal stone formers in north India : a single center study. Saudi Journal of Kidney Diseases and Transplantation. 2013. Vol. 24, no. 4, pp.838-843.
https://search.emarefa.net/detail/BIM-328743
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 842-843
رقم السجل
BIM-328743
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر