Successful management of total knee replacement in a high responder hemophilia patient with a history of inhibitor
المؤلفون المشاركون
Dolatkhah, Roya
Bazavar, Muhammad Rida
Poureisa, Masud
Kermani, Iraj Asvadi
Qara Maliki, Jalal Fayiz
Sanat, Zahrah
Ziaei, Jamal Eivazi
Nikanfar, Ali Rida
Isfahani, Ali
Chavoshi, Sayyid Hadi
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 15، العدد 1 (31 يناير/كانون الثاني 2013)، ص ص. 18-20، 3ص.
الناشر
تاريخ النشر
2013-01-31
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
3
التخصصات الرئيسية
الموضوعات
الملخص EN
The development of inhibitors against administered clotting factors may render replacement therapy ineffective for some hemophilia patients.
Such patients are therefore at the highest risk of developing arthropathy.
Elective orthopedic surgery (EOS) in hemophilic patients having such inhibitors remains a rare, expensive, and difficult surgery, whose management represents a significant challenge.
We report the case of a 35-year-old man with a severe form of hemophilia A (factor VIII < 1%), who was suffering from repetitive spontaneous hemarthrosis, especially in his knee joints that had consequently become more susceptible to bleeding.
The patient had a history of high levels of factor VIII inhibitor (> 5.0 Bethesda Unit [BU] / ml) as shown by the factor VIII inhibitor assay ; therefore, we began treatment with factor VIIa for his mildto- moderate bleeding (90 μg / kg intravenous bolus injections).
The interval between injections varied with the severity of the hemorrhage in each bleeding episode.
The inhibitor level reduced to 3.1 BU / ml after three months, to 1.6 BU / ml after six months, and disappeared completely after one year of treatment.
We administered factor VIII at a dose of 50 IU/kg every eight hours during the first three post-operative days, then continued administration with a dose of 40 IU / kg every 12 hours for another four days, and observed a very good response to treatment with no bleeding.
Recombinant activated factor VII (rFVIIa) is not an inhibitor-removal strategy, but an inhibitor-bypassing product.
However, in our patient, the treatment of mild-to-moderate bleeding with short-term use of rFVIIa and no exposure to factor VIII caused a gradual reduction in the inhibitor level over a period of 1 year.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dolatkhah, Roya& Bazavar, Muhammad Rida& Poureisa, Masud& Kermani, Iraj Asvadi& Qara Maliki, Jalal Fayiz& Sanat, Zahrah…[et al.]. 2013. Successful management of total knee replacement in a high responder hemophilia patient with a history of inhibitor. Iranian Red Crescent Medical Journal،Vol. 15, no. 1, pp.18-20.
https://search.emarefa.net/detail/BIM-329046
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dolatkhah, Roya…[et al.]. Successful management of total knee replacement in a high responder hemophilia patient with a history of inhibitor. Iranian Red Crescent Medical Journal Vol. 15, no. 1 (2013), pp.18-20.
https://search.emarefa.net/detail/BIM-329046
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dolatkhah, Roya& Bazavar, Muhammad Rida& Poureisa, Masud& Kermani, Iraj Asvadi& Qara Maliki, Jalal Fayiz& Sanat, Zahrah…[et al.]. Successful management of total knee replacement in a high responder hemophilia patient with a history of inhibitor. Iranian Red Crescent Medical Journal. 2013. Vol. 15, no. 1, pp.18-20.
https://search.emarefa.net/detail/BIM-329046
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 20
رقم السجل
BIM-329046
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر