The effect of vitamin A supplementation on biochemical parameters in multiple sclerosis patients

المؤلفون المشاركون

Jafarirad, Samyah
Siassi, Firiydun
Harirchian, Muhammad Husayn
Amani, Rida
Bitarafan, Sama
Yaraghi, Ali Akbar Sabur

المصدر

Iranian Red Crescent Medical Journal

العدد

المجلد 15، العدد 3 (31 مارس/آذار 2013)، ص ص. 194-198، 5ص.

الناشر

المستشفى الإيراني

تاريخ النشر

2013-03-31

دولة النشر

الإمارات العربية المتحدة

عدد الصفحات

5

التخصصات الرئيسية

الطب البشري

الموضوعات

الملخص EN

Background : Vitamin A has different functions in the body and after being converted to acid form ; it can play many roles in immune system regulation.

Therefore, this vitamin can be used as a supplement in the treatment of diseases, such as cancer and autoimmune diseases.

Vitamin A is a fat-soluble compound and its long-term consumption in high doses can have some adverse effects.

Objective : The current study aimed to investigate the possible complications and find solutions to minimize the adverse effects.

Patients and Methods : This study was a double blind randomized clinical trial.

In the main study, vitamin A (as retinyl palmitate) was given to 35 multiple sclerosis (MS) patients in order to regulate their immune system with a dose of 25000 IU / day for a period of six months.

To investigate the possible biochemical complications, lipid profiles, fasting blood sugar (FBS), liver enzymes, and C-reactive protein (CRP) were tested.

Results : Vitamin A did not have a significant difference in lipid profiles, FBS and liver enzymes between the two groups receiving vitamin A and the placebo, but CRP increased in patients who were taking vitamin A, 1.65 ± 0.43 (mg / L) and 2.88 ± 0.67, (Mean ± SEM), before and after the intervention respectively (P = 0.029), and statistical analysis showed significant differences with the group receiving placebo (P = 0.011) and CRP level in vitamin A group was 1.3 mg / L more than those of the placebo group after intervention (P = 0.011).

Conclusions : Considering that no significant difference was found in the proven vitamin A side effects, due to the increase in CRP, frequent clinical and biochemical controls are required along with vitamin A supplementation.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Jafarirad, Samyah& Siassi, Firiydun& Harirchian, Muhammad Husayn& Amani, Rida& Bitarafan, Sama& Yaraghi, Ali Akbar Sabur. 2013. The effect of vitamin A supplementation on biochemical parameters in multiple sclerosis patients. Iranian Red Crescent Medical Journal،Vol. 15, no. 3, pp.194-198.
https://search.emarefa.net/detail/BIM-329052

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Jafarirad, Samyah…[et al.]. The effect of vitamin A supplementation on biochemical parameters in multiple sclerosis patients. Iranian Red Crescent Medical Journal Vol. 15, no. 3 (2013), pp.194-198.
https://search.emarefa.net/detail/BIM-329052

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Jafarirad, Samyah& Siassi, Firiydun& Harirchian, Muhammad Husayn& Amani, Rida& Bitarafan, Sama& Yaraghi, Ali Akbar Sabur. The effect of vitamin A supplementation on biochemical parameters in multiple sclerosis patients. Iranian Red Crescent Medical Journal. 2013. Vol. 15, no. 3, pp.194-198.
https://search.emarefa.net/detail/BIM-329052

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references : p. 197-198

رقم السجل

BIM-329052