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Twenty years of experience on stem cell transplantation in Iran
المؤلفون المشاركون
Ghavamzadeh, Ardeshir
Ali Muqaddam, Kamran
Ghaffari, Fatimah
Derakhshandeh, Roshanak
Jalali, Arash
Jahani, Muhammad
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 15، العدد 2 (28 فبراير/شباط 2013)، ص ص. 93-100، 8ص.
الناشر
تاريخ النشر
2013-02-28
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Hematopoietic stem cell transplantation (HSCT) is a new window to therapy of many diseases.
From March 1991 through April 2011, a total of 3237 HSCT were performed in the Hematology-Oncology and Stem Cell Transplantation Research Center, affiliated to Tehran University of Medical Sciences.
Here we report 20 years experience of HSCT.
Objectives : Our strategy and aim include the protraction of cytogenetic and molecular biological diagnostic tests, the expansion of the first Iranian Cord Blood Bank (ICBB) and development of the first Iranian Stem Cell Donor Program (ISCDP), and improvement the researches in new therapeutic fields.
Patients and Methods : Totally, 3237 patients were undergone HSCT.
Of these transplants, 2205 were allogeneic stem cell transplantation, 1016 autologous and 16 syngeneic.
Among 2205 patients who were undergone allogenic-HSCT, 34 received cord blood stem cells as stem cell source for transplantation.
It is important to point out that cord blood bank at our center provides reliable storage of cord blood stem cells for our patients.
Stem cell transplantation was performed for treatment of various diseases such as acute myelogenous leukemia, acute lymphoblastic leukemia, chronic myelogenous leukemia, chronic lymphoblastic leukemia, beta-thalassemia major, sickle- cell thalassemia, sickle- cell disease, multiple myeloma, myelodysplasia, mucopolysaccharidosis, paroxysmal nocturnal hemoglobinuria, non-Hodgkin’s lymphoma, Hodgkin’s disease, severe aplastic anemia, plasma cell leukemia, Niemann-Pick disease, Fanconi anemia, severe combined immunodeficiency, congenital neutropenia, leukocyte adhesion deficiencies, Chediak-Higashi syndrome, osteopetrosis, histiocytosis X, Hurler syndrome, amyloidosis, systemic sclerosis, breast cancer, Ewing's sarcoma, testicular cancer, germ cell tumors, neuroblastoma, medulloblastoma, renal cell carcinoma, nasopharyngeal carcinoma, ovarian cancer, Wilms’ tumor, rhabdomyosarcoma, pancreatoblastoma, and multiple sclerosis.
Also, we had 220 cellular therapies for post-myocardial infarction, multiple sclerosis, cirrhosis, head of femur necrosis, Diabetes Mellitus and GvHD treatment.
45 patients were undergone retransplantation in this center.
Results : About 78.2 % of the patients (2530 of 3237) remained alive between one to 211 months after stem cell transplantation.
Nearly, 21.8 % (707) of our patients died after stem cell transplantation.
The main causes of death were relapse, infection, hemorrhagic cystitis, graft-versus- host disease and etc.
Conclusions : In Iran, HSCT has been successfully adapted in routine clinical care.
Recently, new methods such as double cord blood and haploidentical transplantation have been used to treat many life-threatening diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ghavamzadeh, Ardeshir& Ali Muqaddam, Kamran& Ghaffari, Fatimah& Derakhshandeh, Roshanak& Jalali, Arash& Jahani, Muhammad. 2013. Twenty years of experience on stem cell transplantation in Iran. Iranian Red Crescent Medical Journal،Vol. 15, no. 2, pp.93-100.
https://search.emarefa.net/detail/BIM-329090
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ghavamzadeh, Ardeshir…[et al.]. Twenty years of experience on stem cell transplantation in Iran. Iranian Red Crescent Medical Journal Vol. 15, no. 2 (2013), pp.93-100.
https://search.emarefa.net/detail/BIM-329090
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ghavamzadeh, Ardeshir& Ali Muqaddam, Kamran& Ghaffari, Fatimah& Derakhshandeh, Roshanak& Jalali, Arash& Jahani, Muhammad. Twenty years of experience on stem cell transplantation in Iran. Iranian Red Crescent Medical Journal. 2013. Vol. 15, no. 2, pp.93-100.
https://search.emarefa.net/detail/BIM-329090
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 99-100
رقم السجل
BIM-329090
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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