Improved synthesis of 3-(α, α-diphenyl-α-hydroxymethyl)‎-4-amino 1, 2, 4-triazoline-5-thione and facile route to 3, 6-disubstituted 1, 2, 4-triazolo [3, 4-b] [1, 3, 4] thiadiazoles

الملخص EN

The reaction of thiocarbohydrazide (1) with benzilic acid (2) at the melting temperature (160-170 °C) allows an improved preparation of 3-(α,α-diphenyl-α- hydroxymethyl)-4-amino-1,2,4-triazoline-5-thione (3).

The compound (3) reacts easily with suitable carboxylic acids in presence of phosphorous oxychloride to afford 1, 2, 4-triazolo [3, 4-b] [1, 3, 4] thiadiazole ring systems (4 a-g).

The synthesized products were confirmed by physical and spectral methods.