Treatment and prevention of Salomellosis in puppies using Lactobacillus acidophilus

الملخص EN

This study was carried out to evaluate the ability of Lactobacillus acidophilus to prevent and treat Salmonella typhimurium in puppies.

In vitro antibiotic sensitivity test of S.

typhimurium was made and the result revealed that Ciprofloxacin is the most effective.Isolation of L.

acidophilus from the intestinal tract of the normal dogs and also revealed that all Lactobacillus strains were biochemically identical to standard strain.

A bacterial strain that had high ability to inhibit the growth of S.

typhimurium in vitro with high ability to adhere to intestinal epithelial cells and tolerate the low pH and bile salts was chosen for the experimental study.

Twenty puppies were divided into four groups and treated in different ways.

The clinical, haematological and biochemical parameters were obtained from all animals at the period of two days before inoculation until the death of animals of the first group at the sixth day post infection.

The results revealed that , puppies experimentally infected with S.

typhimurium showed both septicemic and gastrointestinal forms of the disease accompanied with isolation of S.typhimurium from the blood and stool throughout the experiment.

The statistical analysis of the results of all parameters among all groups revealed, for the first time, that L.

acidophilus plays an important role in the prevention of S.typhimurium infection in puppies.

It also has high therapeutic effect against S.typhimurium, which was almost similar to that of Ciprofloxacin.