Differential-pulse polarographic determination of doxycycline in serum and urine

الملخص EN

The polarographic behavior of doxycyline has been studied in phosphate buffer at different pH (2-9).

The compound shows four reduction peaks at pH 2-4, three reduction peaks are observed at pH 5 & 6 and only two reduction peaks at pH 7-9.

The best well-defined two peaks observed at pH 7.0, appearing at-1.09 V and - 1.26 V versus Ag / AgCl, sat.

KCl are used in this study for microdetermination of doxycycline.

The lowest experimental determination limit is 1.85 x 10-7 M.

The method is successfully applied to the determination of doxycycline in vivo (serum and urine).