Isolation and identification of phenols and an alkaloidic compound from matricaria chamomilla plant flowers and study of their medicinal activity against the pathogenic bacteria of skin infections

الملخص EN

Phenols and an alkaloidic compound were isolated from Matricaria camomilla plant flowers.

The chemical and physical properties of isolated compounds were studied using qualitative tests, functional groups test , thin layer chromatography (TLC) and infra-red (IR) spectroscopy.

The results showed presence of two phenolic compounds in phenols extract and one alkaloidic compound in alkaloids extract.

The medicinal activity was measured against growth of standard bacterial strains of skin infections were Staphylocoous aureus (positive) (NCTC 6571) and Escherichia coli (negative) (NCTC 5933).

It was found that the concentration of (100 mg / ml) of phenols was the highest activity where it recorded inhibition diameters equal to 22 mm and 20 mm for positive and negative bacteria respectively.

Also the concentration of (100 mg / ml) of the alkaloidic compound, showed the highest inhibition activity where it recorded inhibition diameters equal to 16 mm and 10 mm for positive and negative bacteria respectively.

The minimal inhibitory concentrations (MIC) were estimated for phenols with value 25 mg / ml for both types of pathogenic bacteria and also for alkaloidic compound with values equal to 50 mg / ml and 75 mg / ml for pathogenic positive and negative bacteria respectively.

As a result the alkalloidic compound and phenols are recommended to use them as medicinal substituents for treatment of skin infections instead of used antibiotics but this work demands further clinical studies.