Comparative analysis between levofloxacin and ciprofloxacin to assess their bactericidal activity using antimicrobial susceptibility disk diffusion on isolates obtained from urine samples
المؤلفون المشاركون
al-Qahtani, Munaf Muhammad
al-Absi, Mustafa Falih
المصدر
Journal of the Bahrain Medical Society
العدد
المجلد 24، العدد 2 (30 يونيو/حزيران 2013)، ص ص. 53-55، 3ص.
الناشر
تاريخ النشر
2013-06-30
دولة النشر
البحرين
عدد الصفحات
3
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Urinary tract infection is one of the most common clinical presentations at the Bahrain Defence Force Hospital (BDFH) where fluoroquinolone (ciprofloxacin) is the first-line prescribed antibiotic.
Levofloxacin has recently been added to the antibiotic formulary.
This study was based on culture-positive urine specimens collected in the period February 1 to August 31, 2011.
The objective of this study was to analyze the antimicrobial sensitivity of ciprofloxacin compared to levofloxacin on clinical isolates obtained from patients with UTI at BDFH.
Methods : The sensitivity analysis on both antibiotics was carried out using 5-microgram disk diffusion on 452 isolates obtained from patients.
The in-vitro activity of the two fluoro-quinolones was evaluated based on the zone of inhibition produced by each antibiotic.
The values for the zones were obtained from the Clinical and Laboratory Standards Institute (CLSI-2011).
Results : Overall levofloxacin provided an improved sensitivity response in patients with culture-positive Enterobacteriacae (71 %) as compared to ciprofloxacin (67 %).
In addition, the culture results showed that the most common UTI causative organisms in BDFH were E-coli (63.9 %), followed by Klebsiella pneumoniae (17.3 %), Proteus species (7.1 %) and Pseudomonas aeruginosa (2.7 %).
There was a statistically significant difference (p = .004) in response to the two fluoroquinolones among the four groups of organisms.
Levofloxacin showed statistically significant disk diffusion susceptibility response among E-coli (M = 20.38, 95 % CI [18.69, 22.07]) and Klebsiella pneumoniae (M = 26.33, 95 % CI [24.45, 28.22]) p = .001, while there was no significant difference in disk diffusion susceptibility response among Proteus species and Pseudomonas aeruginosa.
Conclusion : Levofloxacin had a significantly better disk diffusion sensitivity response than ciprofloxacin in patients with E-coli and Klebsiella pneumoniae culture positive urine specimens.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Qahtani, Munaf Muhammad& al-Absi, Mustafa Falih. 2013. Comparative analysis between levofloxacin and ciprofloxacin to assess their bactericidal activity using antimicrobial susceptibility disk diffusion on isolates obtained from urine samples. Journal of the Bahrain Medical Society،Vol. 24, no. 2, pp.53-55.
https://search.emarefa.net/detail/BIM-334408
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Qahtani, Munaf Muhammad& al-Absi, Mustafa Falih. Comparative analysis between levofloxacin and ciprofloxacin to assess their bactericidal activity using antimicrobial susceptibility disk diffusion on isolates obtained from urine samples. Journal of the Bahrain Medical Society Vol. 24, no. 2 (2013), pp.53-55.
https://search.emarefa.net/detail/BIM-334408
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Qahtani, Munaf Muhammad& al-Absi, Mustafa Falih. Comparative analysis between levofloxacin and ciprofloxacin to assess their bactericidal activity using antimicrobial susceptibility disk diffusion on isolates obtained from urine samples. Journal of the Bahrain Medical Society. 2013. Vol. 24, no. 2, pp.53-55.
https://search.emarefa.net/detail/BIM-334408
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 55
رقم السجل
BIM-334408
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر