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Molecular detection of human papillomavirus genotype-16&-18 in tissues from patients with prostate cancer and benign prostatic hyperplasia
المؤلفون المشاركون
Ali, Sad H. Muhammad
al-Mahbubi, Taghrid F.
al-Qirtas, Muhammad A.
المصدر
Journal of the Faculty of Medicine Baghdad
العدد
المجلد 53، العدد 2 (30 يونيو/حزيران 2011)، ص ص. 201-206، 6ص.
الناشر
تاريخ النشر
2011-06-30
دولة النشر
العراق
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : High oncogenic-risk genotypes of human Papillomavirus (HPV) infect a wide range of human cells, including prostate tissue that give rise to benign prostatic hyperplasia and prostatic adenocarcinomas.
Objectives: This study aimed to detect DNA of HPV genotype-16 &18 using in situ hybridization technique in prostatic tissues from benign prostatic hyperplasia and prostatic adenocarcinomas, and elucidate the association between these HPV genotypes and prostatic carcinogenesis.
Patients and methods : Forty-eight (48) formalin-fixed, paraffin embedded prostatic tissue blocks were obtained ,among them (28) tissue biopsies from prostatic carcinoma with different grades and (20) benign prostate hyperplastic tissue blocks as well as (10) apparently normal prostate tissue autopsies which were collected from the archives of Forensic Medicine Institute / Baghdad and used as prostate healthy control groups.
Detection and genotyping of HPV was done by highly sensitive in situ hybridization technique.
Results : The signals of in situ hybridization reactions of both HPV-16 and HPV-18 in prostate cancer cases in the present study was 25% (7 / 28) whereas in BPH, HPV-16 was detected in 45 %( 9 / 20) and HPV-18 was presented in 35 % (7 / 20).
Neither HPV-16 nor HPV-18 was detected in the apparently healthy control group.The percentages of HPV 16 and HPV18 were increasing with advancing of grade of prostate cancer.
Conclusion : Our results indicate that the oncogenic HPV-16 might contribute to the development of subset of prostate tumors.
In addition, HPV16&18 might have a crucial role in progression of the prostate cancer and benign prostatic hyperplasia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Mahbubi, Taghrid F.& Ali, Sad H. Muhammad& al-Qirtas, Muhammad A.. 2011. Molecular detection of human papillomavirus genotype-16&-18 in tissues from patients with prostate cancer and benign prostatic hyperplasia. Journal of the Faculty of Medicine Baghdad،Vol. 53, no. 2, pp.201-206.
https://search.emarefa.net/detail/BIM-334965
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Mahbubi, Taghrid F.…[et al.]. Molecular detection of human papillomavirus genotype-16&-18 in tissues from patients with prostate cancer and benign prostatic hyperplasia. Journal of the Faculty of Medicine Baghdad Vol. 53, no. 2 (2011), pp.201-206.
https://search.emarefa.net/detail/BIM-334965
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Mahbubi, Taghrid F.& Ali, Sad H. Muhammad& al-Qirtas, Muhammad A.. Molecular detection of human papillomavirus genotype-16&-18 in tissues from patients with prostate cancer and benign prostatic hyperplasia. Journal of the Faculty of Medicine Baghdad. 2011. Vol. 53, no. 2, pp.201-206.
https://search.emarefa.net/detail/BIM-334965
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 205-206
رقم السجل
BIM-334965
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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