![](/images/graphics-bg.png)
MRNA in situ hybridization analysis of VEGF in chronic lymphocytic leukemia
المؤلفون المشاركون
Abd al-Majid, Ban Abbas
Jafar, Abd al-Karim M.
al-Rabii, Haytham A. M. J.
المصدر
Journal of the Faculty of Medicine Baghdad
العدد
المجلد 53، العدد 2 (30 يونيو/حزيران 2011)، ص ص. 186-189، 4ص.
الناشر
تاريخ النشر
2011-06-30
دولة النشر
العراق
عدد الصفحات
4
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Several factors render chronic lymphocytic leukemia (CLL) an interesting subject for study by researchers.
These include marked progress in understanding the molecular biology of normal and neoplastic lymphocytes and recent advances in molecular genetics techniques.
Among molecular markers, vascular endothelial growth factor (VEGF), have been widely studied.
Objective : The aim of the study is to evaluate the role of VEGF in the pathogenesis of CLL and its role in disease progression.
Patients, materials and methods : A retrospective cross-sectional study was done on 60 patients with chronic lymphocytic leukemia (45 males & 15 females) compared with 20 controls (anemic patients), all recruited at the Medical City Hospital/ Teaching Laboratories/ Baghdad from January 2004 to December 2007.
The bone marrow biopsy of each was re-examined histologically.
In situ hybridization was performed utilizing biotin labeled VEGF cDNA probes.
Results : The frequency of VEGF positivity was 95 % (57 of 60 cases).
A statistically significant inverse correlation was found between increasing VEGF scores and lower packed cell volume level and lower platelet count.
A statistically significant association was found between advanced modified Rai stage and patients with high score.
In addition, there was a statistically significant positive correlation between increasing scores of VEGF and advancing clinical stage.
Conclusions: The score of VEGF is high among patients with advanced clinical stage of the disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jafar, Abd al-Karim M.& Abd al-Majid, Ban Abbas& al-Rabii, Haytham A. M. J.. 2011. MRNA in situ hybridization analysis of VEGF in chronic lymphocytic leukemia. Journal of the Faculty of Medicine Baghdad،Vol. 53, no. 2, pp.186-189.
https://search.emarefa.net/detail/BIM-335068
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Rabii, Haytham A. M. J.…[et al.]. MRNA in situ hybridization analysis of VEGF in chronic lymphocytic leukemia. Journal of the Faculty of Medicine Baghdad Vol. 53, no. 2 (2011), pp.186-189.
https://search.emarefa.net/detail/BIM-335068
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jafar, Abd al-Karim M.& Abd al-Majid, Ban Abbas& al-Rabii, Haytham A. M. J.. MRNA in situ hybridization analysis of VEGF in chronic lymphocytic leukemia. Journal of the Faculty of Medicine Baghdad. 2011. Vol. 53, no. 2, pp.186-189.
https://search.emarefa.net/detail/BIM-335068
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 189
رقم السجل
BIM-335068
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)