Effects of dexamethasone, estrogen administration on leptin, thyroid, reproductive hormone concentration and lipid profile of female rabbits serum

الملخص EN

The aim of this study investigate the effects of long term administration of Dexamethasone (DEX.) 17 β-estradiol (EST.) on body weight, concentration of some hormones (Leptin, thyroid and reproductive hormone) in addition to determination of lipid profile of female rabbits blood serum. Thirty local rabbits were subdivided randomly and equally into three groups.

The first group was used as a control which injected with normal saline.

The second group was injected daily (0.5mg / kg B.

W) DEX .

Intramuscularly.

The third group was injected subcutaneously daily with 0.3 mg / kg B.

W s / c 17 β-estradiol.

All groups in this study were treated for 60 days, and blood collected every 15 days.

Serum was tested for leptin, LH, FSH, T3, T4 hormones total Cholesterol(TC), HDL(height density lipo-protein), LDL (low density lipo- protein), TG (triglycerides), Body weight was taken every 15 days from the first day. The result showed significant (P ≤ 0.05) decreased in body weight after administration of both dexamethasone (DEX.) and Estrogen (EST.), significant increased in leptin concentration with dexamethasone (DEX.) Treatment while significant decreased with Estrogen (EST.) treatment, in the other hand LH and FSH concentration showed significant decreased in both treatment dexamethasone (DEX.) and Estrogen (EST.) thyroid hormone show significant decreased with dexamethasone (DEX.) Treatment and significant increased T3 and T4 hormone with Estrogen (EST.) treatment as compare with control while the increase in the T4 it was occurred only in the periods (45 and 60) days within treatment groups, lipid profile (TC, TG, LDL, HDL, VLDL) show significant increased with DEX.

treatment while Significant decreased with EST.

treatment.