Oil extract of lorant h us e urope us seeds promotes wound healing

الملخص EN

The efficacy of oil extract of the seeds of Loranthus europeus on wound healing was investigated.

After the preparation of the oil extract, the oil ointment of L.

europeus was prepared.

A preliminary biochemical analysis were carried out to find out the chemical contents of L.

europeus oil extract.

The study involved 18 male rabbits, they were divided equally and randomly into 3 groups depending on post wounding biopsy: p(3'd, 7Ih and l4‘hday post wounding).

Two full thickness cut wounds were done on the both sides of shoulder regions( the left wound as control and the left as treated wound) of each group of animals.

The treated and control wounds were treated continuously with (0.

5mg) oil ointment and Vaseline base respectively, for 14”‘ day twice a day.

All wounds were evaluate macroscopically which included "measurement of contraction rate, daily wound contraction, hyperemia, exudation and scab formation." and microscopically for "neutrophil, macrophage infiltration, re-epithelization, fibroblast proliferation with collagen production and new blood capillary formation".

A Both macroscopic and microscopic results showed the efficacy of L europeus seeds in promoting the healing process significantly as compared with control wounds (P<0.05).

The oil extract treated wounds showed significant increase in hyperemia, exudation and scab formation, neutrophils and macrophages infiltration, fibroblast proliferation with collagen production and formation of new epithelium (re-epithelization), contraction rate and daily wound contraction at 3”’ day post wounding, as compared with control wounds, but these categories showed reduction at 7”‘ day except in macrophages, re—epithelization and ‘ fibroblast with collagen production which all showed significant increase at 7"‘ and 14"‘ days post wounding as compared with control wounds.

The preliminary chemical analysis for oil extract showed the presence of Glycosides, Carbohydrates, Aldehydes & Ketones, Trifrepenoides groups, protein and Polysaccharides, while Alkaloides, Flavonoides and Saponins are absent.