The immunosuppressive effect of staphylococcus aureus mastitis on il-8 activity

الملخص EN

IL-8 is a neutrophil chemoattractant that plays important role in the regulation of inflammatory responses.

The role of IL-8 in the Staphylococcus aureus mastitis has drawn considerable attention in the last years.

The level and extent of the IL-8 transcriptional activity was considered vital to be monitored.

Bovine TaqMan® real-time PCR was employed to examine the IL-8 mRNA transcriptional activity in cattle Asssiut Vet.

Med.

J.

Vol.

54 No.

119 October 2008 experimentally infected with Staphylococcus aureus at the time points 0, 7, 24 and 32 hrs post-infection.

The level of IL-8 transcriptional activity increased at 24 hrs post-infection, however non-significantly the non-significant increase in the IL-8 activity in Staphylococcus aureus mastitis was seen in accordance with results that several studies have reported recently.

It was postulated that Staphylococcus aureus elicits immunosupression by dwonregulating the NF-kB, a major IL-8-inducing factor.