Synthesis and antibactrial study of new 2-Amino-5-Aryl- 1,3-Thiazole-4-Carboxylic acid derivatives

الملخص EN

-2 Amino-5-aryl- 1, 3-thiazole-4-carboxylic acid (A1-A3) were synthesized from the reaction of various aromatic aldehyde with dichloro acetic acid and thiourea.

The synthesis of 2- [(S-aminosulfinim-idoyl) (aryl) methyl] (benzoyl) amino] -5-aryl-1, 3-thiazole-4-carboxylic acid (A22-A30) was perfomed starting from (A1-A3) by two steps using Schiff's base (A4-A12) prepared from the reactant compounds (A1-A3) with different aromatic aldehyde.

Finally two types of imide derivatives were obtained from reactant compounds (A1-A3) with malic anhydride (A31-A33) and phthalic anhydride (A34-A36) in the presence of glacial acetic acid.

All proposed structures were supported by FT-IR and UV-Visible spectroscopic data.