The impact of CYP3A5 and MDR1 polymorphisms on tacrolimus dosage requirements and trough concentrations in pediatric renal transplant recipients
المؤلفون المشاركون
Shilbayih, Suren
Zmeili, Rawan
al-Mardini, Riham Isa
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 24، العدد 6 (31 ديسمبر/كانون الأول 2013)، ص ص. 1125-1136، 12ص.
الناشر
تاريخ النشر
2013-12-31
دولة النشر
السعودية
عدد الصفحات
12
التخصصات الرئيسية
الموضوعات
الملخص EN
Previous international studies demonstrated significant heterogeneity in the tacrolimus (TAC) dose required to attain target blood concentrations, attributed to both genetic and ethnic factors.
While the majority of previous reports on adult recipients of renal, heart and liver transplants have shown a significant effect of CYP3A5*3 single nucleotide polymorphisms (SNPs) on TAC pharmacokinetics (PKs), the impact of multidrug resistance protein 1 (MDR1) and SNPs remains controversial.
Yet, similar data of TAC in pediatric populations, in whom the intra- and inter-subject variations are likely to be even greater, is currently limited.
We aimed to examine the influence of various CYP3A5 and MDR1 genotypes on TAC dose requirements and PKs in the Jordanian pediatric renal transplant population.
Thirty-eight patients were genotyped for CYP3A5*1 and *3 and MDR1 C3435T.
Dose-adjusted trough concentrations (C0 / D) and daily doses (D) were compared among different CYP3A5 and MDR1 genotypes in the early and maintenance phases post-transplant.
Surprisingly, there were no significant differences in D, C0 or C0 / D among the genotypes of CYP3A5 or MDR1 polymorphisms in either the early or the maintenance phase after transplantation, whereas after combining the C0 / D levels of MDR1 C allele expressers, noticeably lower TAC levels were observed as compared with the TT genotype.
However, the difference became not significant beyond 3 months.
Based on a pharmacokinetic evaluation, the independent impact of CYP3A5 SNPs on TAC PKs was not evident, demonstrating the need for further large-scale studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shilbayih, Suren& Zmeili, Rawan& al-Mardini, Riham Isa. 2013. The impact of CYP3A5 and MDR1 polymorphisms on tacrolimus dosage requirements and trough concentrations in pediatric renal transplant recipients. Saudi Journal of Kidney Diseases and Transplantation،Vol. 24, no. 6, pp.1125-1136.
https://search.emarefa.net/detail/BIM-342439
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shilbayih, Suren…[et al.]. The impact of CYP3A5 and MDR1 polymorphisms on tacrolimus dosage requirements and trough concentrations in pediatric renal transplant recipients. Saudi Journal of Kidney Diseases and Transplantation Vol. 24, no. 6 (2013), pp.1125-1136.
https://search.emarefa.net/detail/BIM-342439
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shilbayih, Suren& Zmeili, Rawan& al-Mardini, Riham Isa. The impact of CYP3A5 and MDR1 polymorphisms on tacrolimus dosage requirements and trough concentrations in pediatric renal transplant recipients. Saudi Journal of Kidney Diseases and Transplantation. 2013. Vol. 24, no. 6, pp.1125-1136.
https://search.emarefa.net/detail/BIM-342439
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 1134-1136
رقم السجل
BIM-342439
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر