Synthesis and characterization of five, sevene heterocyclic membered rings

الملخص EN

New compounds containing heterocyclic units have been synthesized.

These compounds include 2-amino 5- phenyl-1, 3, 4-thiadiazole (1) as starting material to prepare the Schiff bases 2N [3-nitrobenzylidene -2 hydroxy benzylidene and 4-N, N-dimethyl aminobenzylidene] -5-phenyl-1, 3, 4-thiadiazole (2abc), 2N [3-nitrophenyl, 2-hydroxyphenyl or 4-N, N dimethylaminophenyl] 3-]2-amino-5-phenyl-1, 3, 4-thiadiazole]-2, 3-dihydro-[1, 3]oxazepine-benzo-4,7-dione] (3abc), 2N [3-nitrophenyl,2-hydroxyphenyl, 4-N, N-dimethylaminophenyl]-3-[2-amino-5-phenyl-1, 3, 4-thiadiazole-2-yl]-2, 3-dihydro-[1,3]oxazepine-4,7-dione [(4abc), 2-N-[3-nitrophenyl, 2-hydroxyphenyl or 4-N, N-dimethylaminophenyl]-3-[2-amino-5-phenyl-1, 3, 4-thiadiazole-2yl]-1, 2, 3-trihydro-benzo-[1, 2-e] [1, 3] diazepine-4,7-dione (5abc), 2N [2- (3-nitrophenyl, 2-hydroxyphenyl or 4-N, N-dimethylaminophenyl)]-4-oxo-1, 3-thiazolidine-3-yl]-2-amino-5-phenyl-1,3,4-thiadiazole (6abc), 2-N-[5-(3-nitrophenyl, 2-hydroxyphenyl or 4-N, N-dimethylaminophenyl)-tetrazolo-1-yl]-2-amino-5-phenyl-1, 3, 4-thiadiazole (7abc), 2-N-[5-(3-nitrophenyl,2-hydroxyphenyl or 4-N, N-dimethylaminophenyl)-3-[2-amino-5-phenyl-1, 3, 4-thiadiazole-2-yl]-2, 3-dihydro-[1, 3]oxazepine-benzo-4,7-dithione (8abc), 2-N-[5-(3-nitrophenyl, 2-hydroxyphenyl or 4-N, N-dimethylaminophenyl)-3-[2-amino-5-phenyl-1,3,4-thiadiazole-2-yl]-2, 3-dihydro-[1, 3]oxazepine -4, 7-dithione -5-ene (9abc) and 2-N- [5- (3-nitrophenyl, 2-hydroxyphenyl or 4-N, N-dimethylaminophenyl)-3-[2-amino-5-phenyl-1,3,4-thiadiazole-2-yl] -1, 2, 3-trihydro-benzo-[1,2-e][1,3] diazepine -4, 7-dithione -(10abc) .

the structures of these compounds were characterized by FT-IR, 1H, 13C-NMR, Uv / vis spectroscopy and the melting points were determined besides the evaluation of its biological activity.