Assessment of iron status and the end-product of lipid peoxidation in ischemic heart disease in male patients

الملخص EN

Objective :In the present study, an attempt is carried out to estimate the degree of iron overload in IHD patients in addition to the measurement of lipid peroxidation end product, malondialdehyde (MDA).

The level of these compounds will indicate the risk of tissue damage caused by oxidative stress and iron overload.

Methodes : Sixty eight patients with ischemic heart diseases including stable angina (AS), unstable angina (UA) and myocardial infarction (MI) (aged 40-60 years) were involved in the present study during their admission to Al-Sader Teaching Hospital / Al-Najaf Al-Ashraf.

Age matched twenty two healthy men were included as control group.

All blood samples were taken early morning from fasting subjects.

Serum levels of iron and total Iron Binding Capacity (TIBC) were measured spectrophotometrically while unsaturated iron-binding capacity (UIBC), estimated total iron body stores (ETIBS), transferrrin saturation percentage (TS %) and transferrin concentration were calculated mathematically.

Serum ferritin and MDA were measured using ELISA technique.

Results : Results of the present study in general revealed that there is a mild state of iron overload in IHD patients in comparing with healthy control.

The results of iron status showed significant increase (P < 0.05) in all iron indices of IHD patients in comparing with healthy control group except TIBC and UIBC, which decrease significantly (P < 0.05) in those patients in comparing with control group.

Moreover, a significant (P < 0.05) increase in serum ferritin and ETIBS was found in IHD patients compared with control group.

Serum MDA is increased significantly in IHD patients as compared with control group.

Conclusions : From the present study, it can be concluded that, iron status parameters showed be uses as a useful routine measures in IHD patients and iron stores in patients reveal a possible role of iron overload in the development of coronary atherosclerosis.

MDA elevation in IHD patients indicating a possible role of oxidative stress processes in the pathophysiology of the heart diseases.

Smoking has adverse effects on MDA and iron status leading, among many other known causes, to increase IHD risk.