ProExC is a novel marker for distinguishing between primary endometrial and endocervical adenocarcinomas
المؤلف
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 25، العدد 2 (30 يونيو/حزيران 2013)، ص ص. 87-93، 7ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2013-06-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : distinguishing end cervical adenocarcinoma (ECA) from endometrial adenocarcinoma (EMA) is clinically significant and cannot always be made on the basis of morphology alone or clinical findings.
The aim of this study was to study the potential utility of Pro ExC as a new marker for cervical adenocarcinoma, and to evaluate a panel of monoclonal antibodies composed of p16, ER, PR, and vimentin, and assess their diagnostic value in distinguishing between ECA and EMA.
Methods : immunohistochemistry using monoclonal antibodies to Pro ExC, p16, estrogen receptor (ER), progesterone receptor (PR), and vimentin, was performed to examine 30 cases, including 10 ECAs and 20 EMAs.
Results : Eight out of 10 cases (80 %) of ECA were positive for Pro ExC, whereas only 2 cases of EMA (10 %) were positive.
The difference of Pro ExC expression in the two groups of malignancy was statistically significant (p = 0.003).
P16 was positive in 8 cases (80 %) of ECAs and in 4 cases 20 % of EMAs.
Estrogen receptor was negative in all cases of ECA, while it was positive in 95 % of EMA.
Progesterone receptor was positive in 2 cases (20 %) of ECA and in 16 cases (80 %) of EMA.
Vimentin was positive in only one case (10 %) of ECA, and in 16 cases (80 %) of EMA.
Conclusion : Pro ExC is a novel immunohistochemical marker for differentiating ECA from EMA and its inclusion in a panel of immunohistochemical markers including p16, ER, PR, and vimentin is recommended when there is morphological and clinical doubt as to the primary site of end cervical or endometrial origin.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Eshiba, Ghadah E.. 2013. ProExC is a novel marker for distinguishing between primary endometrial and endocervical adenocarcinomas. Journal of the Egyptian National Cancer Institute،Vol. 25, no. 2, pp.87-93.
https://search.emarefa.net/detail/BIM-346538
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Eshiba, Ghadah E.. ProExC is a novel marker for distinguishing between primary endometrial and endocervical adenocarcinomas. Journal of the Egyptian National Cancer Institute Vol. 25, no. 2 (Jun. 2013), pp.87-93.
https://search.emarefa.net/detail/BIM-346538
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Eshiba, Ghadah E.. ProExC is a novel marker for distinguishing between primary endometrial and endocervical adenocarcinomas. Journal of the Egyptian National Cancer Institute. 2013. Vol. 25, no. 2, pp.87-93.
https://search.emarefa.net/detail/BIM-346538
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 92-93
رقم السجل
BIM-346538
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر