Thyroid function in patients with chronic hepatitis C virus infection under interferon therapy
المؤلفون المشاركون
Hasan, Muhammad A. M.
al-Dahshan, Tariq
Abd al-Qadir, Muhammad E.
Azmi, Muhammad K.
Ahmad, Yusuf K.
Husayn, Musa A.
المصدر
Journal of the Egyptian Society of Parasitology
العدد
المجلد 42، العدد 3 (31 ديسمبر/كانون الأول 2012)، ص ص. 761-768، 8ص.
الناشر
الجمعية المصرية لعلم الطفيليات
تاريخ النشر
2012-12-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
The study examined 60 HCV patients with normal baseline levels of TSH.
The patients received subcutaneous pegylated interferon α–2b weekly in addition to oral ribavirin.
Before the start of the interferon therapy, serum TSH, thyroglobulin-Ab (TG-Ab) and antiperoxidase antibodies (TPO-Ab) were measured.
Three months after interferon therapy serum levels of TSH were measured to all patients ; patients with abnormal TSH were subjected to the measurements of FT3, FT4, TPOAb.
TG-Ab, and thyroid stimulating immunoglobulin levels (TSI).
After 3 months of therapy, 48 patients (80 %) had normal TSH, and 12 patients (20 %) had abnormal TSH.
Of 12 patients with abnormal TSH 10 (16.6 %) had high levels of TSH hypothyroidism), while the other two (3.4 %) had low levels of TSH (Hyperthyroidism.
Of 10 patients with hypothyroidisms, 6 patients (10 %) had overt hypothyroidism and 4 patients (6.6 %) had subclinical hypothyroidism.
All patients with abnormal TSH had significant higher levels of TG-Ab, TPO-Ab and TSI (in cases with hyperthyroidism only) than the patients with normal levels of TSH (p < 0.001), the levels of TPO-Ab only of the most patients with abnormal TSH were above the normal reference range before the start of interferon therapy.
Patients with hyperthyroidism, one was presented by clinical picture of overt hyperthyroidism, and the second by subclinical hyperthyroidism.
All patients with overt hypo and hyperthyroidism received medical treatment, with normalization of levels of TSH and improvement of clinical symptoms and completed their course of interferon therapy Forty patients (66.6 %) responded to interferon (- ve PCR for HCV), while 20 33.3 % did not respond, 5 had TSH abnormalities that were significantly higher than those in patient with normal TSH {5 / 12 (41.6 %) versus 15 / 48 (31 %) ; p < 0.01}.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Qadir, Muhammad E.& Azmi, Muhammad K.& Hasan, Muhammad A. M.& Ahmad, Yusuf K.& al-Dahshan, Tariq& Husayn, Musa A.. 2012. Thyroid function in patients with chronic hepatitis C virus infection under interferon therapy. Journal of the Egyptian Society of Parasitology،Vol. 42, no. 3, pp.761-768.
https://search.emarefa.net/detail/BIM-347244
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hasan, Muhammad A. M.…[et al.]. Thyroid function in patients with chronic hepatitis C virus infection under interferon therapy. Journal of the Egyptian Society of Parasitology Vol. 42, no. 3 (Dec. 2012), pp.761-768.
https://search.emarefa.net/detail/BIM-347244
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Qadir, Muhammad E.& Azmi, Muhammad K.& Hasan, Muhammad A. M.& Ahmad, Yusuf K.& al-Dahshan, Tariq& Husayn, Musa A.. Thyroid function in patients with chronic hepatitis C virus infection under interferon therapy. Journal of the Egyptian Society of Parasitology. 2012. Vol. 42, no. 3, pp.761-768.
https://search.emarefa.net/detail/BIM-347244
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 767-768
رقم السجل
BIM-347244
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر