Evaluation of cyclodextrin (sugammadex)‎ for reversal of intense neuromuscular block of rocuronium and vecuronium : experimental and clinical studies

الملخص EN

This study evaluated and explored time course, efficacy, relation, safety, changes in heart rate, and blood pressure after a bolus dose of sugammadex or neostigmine for reversal of a prolonged rocuronium and vecuronium induced neuromuscular block.

A total of 60 patients of both sexes, ‘ASA’ grade I, II and all were scheduled for elective surgery of 30-45 minutes duration.

Informed oral consent was obtained from all patients to participate in this study.

The results showed statistically significant progressive decrease of heart rate and blood pressure at 2, 5 and 10 minutes when compared to their basal values before anesthesia, then it starts to gain its normal value at 5 and 10 minutes, regardless the dose of sugammadex (effect of anesthesia).

Also, heart rate and blood pressure showed statistically non-significant variance between groups of sugammadex when compared at any time of the study with the neostigmine groups (i.e.

no effect of the dose on heart rate).