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DJ-1 and androgen receptor immunohistochemical expression in prostatic carcinoma : a possible role in carcinogenesis
المؤلفون المشاركون
Abd al-Ati, Rasha M.
Uthman, Wisam M.
Abu Jabal, Huda H.
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 25، العدد 4 (31 ديسمبر/كانون الأول 2013)، ص ص. 223-230، 8ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2013-12-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Background and Aim : androgen plays a fundamental role in the growth and differentiation of prostate.
Androgen receptor (AR) expression may represent a potential marker of prognosis in prostate cancer.
However, there have been variable results regarding its ability to predict clinical progression.
Despite the oncogenic properties of DJ-1, its significance in prostate cancer development and progression is not well understood.
This research shed some light on the possible role of immunohistochemical expression of DJ-1 in clinically localized prostatic carcinoma in relation to the established role of AR and other clinicopathologic parameters.
Materials and Methods : the immunohistochemical expression of AR and DJ-1 was evaluated samples including benign hyperplasia (n = 60) and prostatic carcinoma (n= 69).
Results: The mean value of AR immunostaining was significantly higher in prostatic carcinomas than in benign hyperplasia (P = 0.001).
A significant inverse correlation was found between AR immunostaining and the grade of prostatic carcinomas.
A significantly higher median DJ-1 score was found in prostatic carcinoma than in benign hyperplasia (P = 0.0001).
There was a significant direct correlation between AR and DJ-1 score (P =0.0001).
AR is more sensitive in predicting prostatic carcinoma than DJ-1 but DJ-1 is more specific than AR.
Conclusion: AR nuclear expression was consistently present in benign and adenocarcinoma epithelium.
But, there may be limited clinical use for AR expression in localized carcinoma due to its constant heterogeneity.
DJ-1 with its oncogenic properties, specificity for prostatic carcinoma and homogenous expression gives an ideal complementary role to AR in the detection and treatment of prostatic carcinomas.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Uthman, Wisam M.& Abd al-Ati, Rasha M.& Abu Jabal, Huda H.. 2013. DJ-1 and androgen receptor immunohistochemical expression in prostatic carcinoma : a possible role in carcinogenesis. Journal of the Egyptian National Cancer Institute،Vol. 25, no. 4, pp.223-230.
https://search.emarefa.net/detail/BIM-347918
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Uthman, Wisam M.…[et al.]. DJ-1 and androgen receptor immunohistochemical expression in prostatic carcinoma : a possible role in carcinogenesis. Journal of the Egyptian National Cancer Institute Vol. 25, no. 4 (Dec. 2013), pp.223-230.
https://search.emarefa.net/detail/BIM-347918
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Uthman, Wisam M.& Abd al-Ati, Rasha M.& Abu Jabal, Huda H.. DJ-1 and androgen receptor immunohistochemical expression in prostatic carcinoma : a possible role in carcinogenesis. Journal of the Egyptian National Cancer Institute. 2013. Vol. 25, no. 4, pp.223-230.
https://search.emarefa.net/detail/BIM-347918
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 229-230
رقم السجل
BIM-347918
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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