Additional effect of diabetes mellitus type 2 on the risk of coronary artery disease : role of serum adiponectin
المؤلفون المشاركون
Muhammadzadah, Ghurban
Ghaffari, Muhammad Ali
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 16، العدد 1 (31 يناير/كانون الثاني 2014)، ص ص. 1-7، 7ص.
الناشر
تاريخ النشر
2014-01-31
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: Adiponectin, an adipocyte-derived hormone, is implicated in diabetes mellitus type 2 and atherosclerosis.
The study was designed to investigate whether serum adiponectin levels in patients with both coronary artery disease (CAD) and diabetes mellitus type 2 (T2DM) are lower than in patients with CAD alone and control subjects.
Objectives : in this present study, we measured serum adiponectin levels in consecutive CAD patients with and without T2DM and investigated whether decreased adiponectin is associated with risk factors of CAD.
Materials and Methods : the study included 198 subjects, 138 patients with CAD (72 of whom had both CAD and T2DM), and 60 control subjects.
We measured serum adiponectin, interleukin-6 (IL-6) and insulin by ELISA.
In addition, Lipid profile, glucose and anthropometrical measurements were performed in all subjects.
Results : the results revealed significant difference in serum adiponectin levels between patients with CAD+T2DM and patients with CAD alone (3.80 ± 1.52 vs.
5.25 ± 2.35, P = 0.007), between patients with CAD and control (5.25 ± 2.35 vs.
7.04 ± 3.32, P = 0.001), and between patients with CAD + T2DM and control (3.80 ± 1.52 vs.
7.04 ± 3.32, P < 0.001).
Serum adiponectin level was significantly higher in women in contrast to men (5.97 ± 3.15 vs.
4.62 ± 2.81 μg / ml, P = 0.002).
Serum adiponectin levels were correlated significantly with insulin (r = -0.178, P = 0.013), total cholesterol (r = -0.313, P < 0.001), low density lipoprotein (r = -0.154, P = 0.016), body mass index (r = -0.171, P = 0.016), glucose (r = -0.202, P = 0.006), HOMA-IR (r= -0.251, P = 0.001), and IL-6 levels (r = -0.321, P = 0.001).
Adiponectin was correlated positively only with high density lipoprotein (r = 0.389, P < 0.001).
Conclusions : it is speculated that increased insulin resistance and increase in other adipokines such as IL-6 may contribute to the decreased serum levels of adiponectin in patients with both CAD and T2DM.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Muhammadzadah, Ghurban& Ghaffari, Muhammad Ali. 2014. Additional effect of diabetes mellitus type 2 on the risk of coronary artery disease : role of serum adiponectin. Iranian Red Crescent Medical Journal،Vol. 16, no. 1, pp.1-7.
https://search.emarefa.net/detail/BIM-350442
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Muhammadzadah, Ghurban& Ghaffari, Muhammad Ali. Additional effect of diabetes mellitus type 2 on the risk of coronary artery disease : role of serum adiponectin. Iranian Red Crescent Medical Journal Vol. 16, no. 1 (Jan. 2014), pp.1-7.
https://search.emarefa.net/detail/BIM-350442
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Muhammadzadah, Ghurban& Ghaffari, Muhammad Ali. Additional effect of diabetes mellitus type 2 on the risk of coronary artery disease : role of serum adiponectin. Iranian Red Crescent Medical Journal. 2014. Vol. 16, no. 1, pp.1-7.
https://search.emarefa.net/detail/BIM-350442
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 6-7
رقم السجل
BIM-350442
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر