In vitro study of the effect of some drugs on Leishmania Donavani replication rate

الملخص EN

The effect of some drugs on growth rate of lishmania donovani have been estimated.

The drugs used have different mechanisms of action, some of them tested on leishmania donavani for the first time.

The following drugs used like levamisole in a dose (1 mg / ml), metronidazole (1 mg / ml), bromohexine (0.02 mg / ml), sildenafil (0.5 mg/ml) show significant inhibition of L.

donavani promastigotes proliferation while paracetamole in a dose of (0.1 mg / ml) enhance the promastigotes growth, meanwhile diclofenac sodium in a dose of (0.5 mg / ml) show little or no effect on growth rate.

Also metronidazole and levamisole in a dose of (0.5 mg / ml) has no effect on growth rate.

The inhibitory effect of drugs appears from the first day of experiment and fluctuated in second and third days .The effect of paracetamole is continuous throughout the 3 days of experiment.

On the other hand, the effect of diclofenac sodium unnoticeable till the third day.