Synthesis and characterization of some β-lactams derivatives from 5-phenyl valeric acide

الملخص EN

A series of 3-(3-phenylpropyl)azetidine-2-one 3(a-d), have been synthesized via Schiff bases 2(a-d) in the presence of triethylamine with phosphorusoxychloride using GU \ PHWK \ OHQHFKORULGH XQGHU QLWURJHQDWPRVSKHUHDW Û& 7KHDFWLYHDFLGFKORULGHreacts with triethylamine to generate corresponding ketene in situ which further react ZLWK 6FKLII¶V EDVH WR IXUQLVK WKH corresponding 3-(3-phenylpropyl) azetidine-2-one 3(a-d) in moderate yields.

The mass spectroscopy confirms the molecular weight of the prepared compound.

Furthermore, the two dimensional NM HMQC 1H-13C, COSY 1H ± 1H was used to confirm the proposed structure.