Chemical constituents and protective effect of Ficus ingens (Miq.) Miq. on carbon tetrachloride-induced acute liver damage in male wistar albino rats
المؤلفون المشاركون
Awwad, Amani S.
Sulayman, Jamal A.
Dunya, Abd al-Rahim M.
Zaghlul, Ahmad M.
al-Qasumi, Salih I.
Radwan, Asma M.
Basudan, Umar A.
المصدر
Journal of Saudi Chemical Society
العدد
المجلد 17، العدد 1 (31 يناير/كانون الثاني 2013)، ص ص. 125-133، 9ص.
الناشر
تاريخ النشر
2013-01-31
دولة النشر
السعودية
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
The aim of the present study was to investigate the chemical constituents and hepatoprotective effect of Ficus ingens (Miq.) Miq.
(Moraceae) extract against carbon tetrachloride-induced acute liver damage in male Wistar albino rats.
The ethanol extract of F.
ingens, was subjected to phytochemical study.
In addition, its acute and sub-chronic toxicities were assessed.
Eight compounds were isolated from this plant and identified as b-sitosterol, b-sitosterol glucoside, chryasophanol, hydroxy-2,5 dimethyl chromen-4-one, quercetin, Aloe emodin glucoside, rutin and Patuletin-30-O-methyl-3-O-rutinoside.
The structure elucidation was based on 1H and 13C NMR, proton–proton correlation spectroscopy (1H–1H Cosy), distortionless enhancement by polarization transfer (DEPT), Heteronuclear Multiple-Quantum Correlation (HMQC), and heteronuclear multiple bond correlations spectrum (HMBC).
Hepatotoxicity induced with CCl4 was evidenced by elevation of liver marker enzymes (ALT, AST, ALP and LDH) and TB content in serum.
In addition, antioxidant enzymes were drastically inhibited with significant reduction of GSH and increased LPO in liver homogenate of CCl4-intoxicated rats.
Pre-treatment with F.
ingens (200 and 400 mg / kg) and silymarin (50 mg / kg) avoided the changes observed in CCl4-intoxicated rats.
In conclusion, the ethanol extract of F.
ingens showed protective activity against liver injury, which might be developed into a new hepatoprotective agent.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dunya, Abd al-Rahim M.& Sulayman, Jamal A.& Zaghlul, Ahmad M.& al-Qasumi, Salih I.& Awwad, Amani S.& Radwan, Asma M.…[et al.]. 2013. Chemical constituents and protective effect of Ficus ingens (Miq.) Miq. on carbon tetrachloride-induced acute liver damage in male wistar albino rats. Journal of Saudi Chemical Society،Vol. 17, no. 1, pp.125-133.
https://search.emarefa.net/detail/BIM-351576
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dunya, Abd al-Rahim M.…[et al.]. Chemical constituents and protective effect of Ficus ingens (Miq.) Miq. on carbon tetrachloride-induced acute liver damage in male wistar albino rats. Journal of Saudi Chemical Society Vol. 17, no. 1 (Jan. 2013), pp.125-133.
https://search.emarefa.net/detail/BIM-351576
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dunya, Abd al-Rahim M.& Sulayman, Jamal A.& Zaghlul, Ahmad M.& al-Qasumi, Salih I.& Awwad, Amani S.& Radwan, Asma M.…[et al.]. Chemical constituents and protective effect of Ficus ingens (Miq.) Miq. on carbon tetrachloride-induced acute liver damage in male wistar albino rats. Journal of Saudi Chemical Society. 2013. Vol. 17, no. 1, pp.125-133.
https://search.emarefa.net/detail/BIM-351576
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 132-133
رقم السجل
BIM-351576
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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