Quantitative determination of lansoprozole in capsules and spiked human urine by spectrophotometry through ion-pair complex formation reaction
المؤلفون المشاركون
Vinay, Kanakapura Basavaiah
Devi, Okram Zenita
Basavaiah, Kanakapura
المصدر
Journal of Saudi Chemical Society
العدد
المجلد 17، العدد 4 (31 أكتوبر/تشرين الأول 2013)، ص ص. 387-396، 10ص.
الناشر
تاريخ النشر
2013-10-31
دولة النشر
السعودية
عدد الصفحات
10
التخصصات الرئيسية
الموضوعات
الملخص EN
Two simple, rapid and sensitive extraction-free spectrophotometric methods are proposed for the determination of lansoprazole (LAN) in bulk drug and in its capsule formulation.
The methods are based on the interaction of LAN in dichloromethane (DCM) with acidic sulfonphthalein dyes, namely, bromocresol purple (BCP) in method A and bromothylmol blue (BTB) in method B to form stable, yellow-colored, ion-pair complexes peaking at 400 and 430 nm, respectively.
The parameters that affect the reaction were carefully optimized, and under the optimized conditions, linear relationships were obtained in the ranges of 0.5–15.0 and 1.25–20.0 lg mL 1 LAN for method A and method B, respectively.
The molar absorptivity values are calculated to 1 be 2.10 104 and 1.50 • 104 L mol for method A and method B, respectively.
The composition of the ion-pairs was found to be 1 : 1 by Job’s method of continuous variations and the conditional stability constant (log Kf) of the complexes has been calculated.
The proposed methods were applied successfully to the determination of LAN in capsules as well as in spiked urine sample with good accuracy and precision.
The results obtained by the proposed methods were compared favorably with those of the reference method.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Devi, Okram Zenita& Basavaiah, Kanakapura& Vinay, Kanakapura Basavaiah. 2013. Quantitative determination of lansoprozole in capsules and spiked human urine by spectrophotometry through ion-pair complex formation reaction. Journal of Saudi Chemical Society،Vol. 17, no. 4, pp.387-396.
https://search.emarefa.net/detail/BIM-351727
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Devi, Okram Zenita…[et al.]. Quantitative determination of lansoprozole in capsules and spiked human urine by spectrophotometry through ion-pair complex formation reaction. Journal of Saudi Chemical Society Vol. 17, no. 4 (Oct. 2013), pp.387-396.
https://search.emarefa.net/detail/BIM-351727
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Devi, Okram Zenita& Basavaiah, Kanakapura& Vinay, Kanakapura Basavaiah. Quantitative determination of lansoprozole in capsules and spiked human urine by spectrophotometry through ion-pair complex formation reaction. Journal of Saudi Chemical Society. 2013. Vol. 17, no. 4, pp.387-396.
https://search.emarefa.net/detail/BIM-351727
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 394-395
رقم السجل
BIM-351727
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر