Therapeutic effect of oral nicotinamide on refractory uremic : a randomized, double-blind study
المؤلفون المشاركون
Amidian, Muhammad
Khazani, Ahmad
Yaqubi, Rida
Qurbani, Ali Rida
Pazyar, Nadir
Biladi Musawi, Sayyid Sayf Allah
Ghadimi, Mahmud Rida
Mohebbipour, Ali Rida
Fily, Amir
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 24، العدد 5 (30 سبتمبر/أيلول 2013)، ص ص. 995-999، 5ص.
الناشر
تاريخ النشر
2013-09-30
دولة النشر
السعودية
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
To determine the efficacy of oral nicotinamide with placebo to ameliorate uremic pruritus (UP), we conducted a prospective, randomized, double-blind, 4-week study in 50 chronic kidney disease patients with refractory UP.
The patients were randomly allocated to nicotinamide tablet 500 mg twice/day or placebo.
All anti-pruritic agents were discontinued at least two weeks before the study.
All the patients completed the period of the study and their severity of pruritus was evaluated before the start of the study and at the end of each week for four weeks by using a traditional Visual Analogue Scale and a modified questionnaire method (pruritus score).
The average pruritus score before administration of oral nicotinamide in the study group and that in the placebo group was 2.96 ± 0.45 and 2.72 ± 0.37, respectively.
In the nicotinamide group, the average score of pruritus gradually reduced to 1.29 ± 1.08 and in the placebo group it gradually decreased to 1.52 ± 1.61 at the end of the fourth week.
There was no significant difference between the reductions of pruritus in both groups, but the interaction effect using a linear mixed model was significant between drug and time (P <0.026).
We conclude that increasing the time of application of nicotinamide sodium to more than four weeks may be more effective than placebo in reducing itching in uremic patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Amidian, Muhammad& Khazani, Ahmad& Yaqubi, Rida& Qurbani, Ali Rida& Pazyar, Nadir& Biladi Musawi, Sayyid Sayf Allah…[et al.]. 2013. Therapeutic effect of oral nicotinamide on refractory uremic : a randomized, double-blind study. Saudi Journal of Kidney Diseases and Transplantation،Vol. 24, no. 5, pp.995-999.
https://search.emarefa.net/detail/BIM-355450
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Qurbani, Ali Rida…[et al.]. Therapeutic effect of oral nicotinamide on refractory uremic : a randomized, double-blind study. Saudi Journal of Kidney Diseases and Transplantation Vol. 24, no. 5 (2013), pp.995-999.
https://search.emarefa.net/detail/BIM-355450
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Amidian, Muhammad& Khazani, Ahmad& Yaqubi, Rida& Qurbani, Ali Rida& Pazyar, Nadir& Biladi Musawi, Sayyid Sayf Allah…[et al.]. Therapeutic effect of oral nicotinamide on refractory uremic : a randomized, double-blind study. Saudi Journal of Kidney Diseases and Transplantation. 2013. Vol. 24, no. 5, pp.995-999.
https://search.emarefa.net/detail/BIM-355450
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references: p. 998-999
رقم السجل
BIM-355450
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر