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Role of expression of endothelin-1 and angiotensin-II and hypoxia-inducible factor-1α in the kidney tissues of patients with diabetic nephropathy
المؤلفون المشاركون
Sagar, Shrestha Kumar Duwal
Zhang, Cuicui
Guo, Qing
Yi, Run
Lin-Tang
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 24، العدد 5 (30 سبتمبر/أيلول 2013)، ص ص. 959-964، 6ص.
الناشر
تاريخ النشر
2013-09-30
دولة النشر
السعودية
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
The objective of this study was to detect the expression of Angiotensin-II (Ang-II), Hypoxia-inducible factor-1α (HIF-1α) and Endothelin-1 (ET-1) in the kidneys of patients with diabetic nephropathy (DN) and to investigate their relationship with renal interstitial fibrosis (RIF).
A total of 47 paraffin specimens of patients with DN and six controls were enrolled in this study, and all were diagnosed by histopathology.
We studied the expressions of Ang-II, HIF-1α and ET-1 by immuno-histochemical staining and the level of RIF by Masson staining.
The following results were found: (a) RIF existed in the kidneys of patients with DN, (b) the expressions of Ang-II, HIF-1α and ET-1 were lower in the control group but increased significantly in the DN group, (c) the expression of Ang-II, HIF-1α and ET-1 in tubular epithelial cells directly correlated with RIF (rs = 0.659, 0.633, 0.716, P <0.01) and (d) the expression of Ang-II, ET-1 and HIF-1α in the kidneys of patients with DN positively correlated with serum creatinine (Scr) levels (rs = 0.391, 0.594, 0.531, P <0.01) but they did not correlate with the 24-h urinary protein, blood glucose and serum albumin levels.
These results provide new insights suggesting that overexpression of Ang-II, HIF-1α and ET-1 promote the progression of RIF in DN.
Thus, targeting reduction in the expression of Ang-II, HIF-1α and ET-1 can delay RIF in DN.
Further studies are needed to validate this observation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sagar, Shrestha Kumar Duwal& Zhang, Cuicui& Guo, Qing& Yi, Run& Lin-Tang. 2013. Role of expression of endothelin-1 and angiotensin-II and hypoxia-inducible factor-1α in the kidney tissues of patients with diabetic nephropathy. Saudi Journal of Kidney Diseases and Transplantation،Vol. 24, no. 5, pp.959-964.
https://search.emarefa.net/detail/BIM-355820
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sagar, Shrestha Kumar Duwal…[et al.]. Role of expression of endothelin-1 and angiotensin-II and hypoxia-inducible factor-1α in the kidney tissues of patients with diabetic nephropathy. Saudi Journal of Kidney Diseases and Transplantation Vol. 24, no. 5 (2013), pp.959-964.
https://search.emarefa.net/detail/BIM-355820
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sagar, Shrestha Kumar Duwal& Zhang, Cuicui& Guo, Qing& Yi, Run& Lin-Tang. Role of expression of endothelin-1 and angiotensin-II and hypoxia-inducible factor-1α in the kidney tissues of patients with diabetic nephropathy. Saudi Journal of Kidney Diseases and Transplantation. 2013. Vol. 24, no. 5, pp.959-964.
https://search.emarefa.net/detail/BIM-355820
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 963-964
رقم السجل
BIM-355820
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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